In this review, we provide an overview of protein synthesis in the yeast Saccharomyces
cerevisiae. The mechanism of protein synthesis is well conserved between yeast and other …

Protein synthesis stands at the last stage of the central dogma of molecular biology,
providing a final regulatory layer for gene expression. Reacting to environmental cues and …

Ribosome profiling suggests that ribosomes occupy many regions of the transcriptome
thought to be noncoding, including 5′ UTRs and long noncoding RNAs (lncRNAs) …

Emerging studies have linked the ribosome to more selective control of gene regulation.
However, an outstanding question is whether ribosome heterogeneity at the level of core …

Regulation of messenger RNA translation is central to eukaryotic gene expression control.
Regulatory inputs are specified by the mRNA untranslated regions (UTRs) and often target …

Translational control targeting the initiation phase is central to the regulation of gene
expression. Understanding all of its aspects requires substantial technological …

Assembly factors (AFs) prevent premature translation initiation on small (40S) ribosomal
subunit assembly intermediates by blocking ligand binding. However, it is unclear how AFs …

Message-specific translational control is required for gametogenesis. In yeast, the RNA-
binding protein Rim4 mediates translational repression of numerous mRNAs, including the …

Protein synthesis by ribosomes is critically important for gene expression in all cells.
Ribosomal RNAs (rRNAs) are marked by numerous chemical modifications. An abundant …

Abstract Poly (A)-binding protein (PABP) is a major component of the messenger RNA–
protein complex. PABP is able to bind the poly (A) tail of mRNA, as well as translation …