Nicotinamide adenine dinucleotide (NAD) is an important coenzyme that participates in
various energy metabolism pathways, including glycolysis, β-oxidation, and oxidative …

Calcium (Ca2+) is an almost universal intracellular messenger, controlling a diverse range
of cellular processes, such as gene transcription (see Mellström and Naranjo, this issue) …

Gap junctions consist of intercellular channels that connect the cytoplasm of adjacent cells
directly and allow the exchange of small molecules. These channels are unique in that they …

A decrease in the intracellular level of nicotinamide adenine dinucleotide (NAD+), an
essential coenzyme for metabolic activity, causes various age-related diseases and …

Since the beginning of the last century, seminal discoveries have identified pyridine
nucleotides as the major redox carriers in all organisms. Recent research has unravelled an …

ABSTRACT A previously unrecognized passive transport for pyridine dinucleotides has
been described recently in the plasmamembrane of several mammalian cells. Despite …

Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP)
are two Ca2+ messengers derived from NAD and NADP, respectively. Although NAADP is a …

The metabolism of NAD has emerged as a key regulator of cellular and organismal
homeostasis. Being a major component of both bioenergetic and signaling pathways, the …

CD38, a multifunctional enzyme, generates two potent Ca2+‐releasing signal metabolites,
cyclic ADP‐ribose (cADPR) and NAADP+, thereby upmodulating many important Ca2+ …

Mobilization of intracellular Ca2+ stores is involved in many diverse cell functions, including:
cell proliferation; differentiation; fertilization; muscle contraction; secretion of …