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Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently
The amino acid sequence of a protein affects both its structure and its function. Thus, the
ability to modify the sequence, and hence the structure and activity, of individual proteins in …
ability to modify the sequence, and hence the structure and activity, of individual proteins in …
Engineering biological systems using automated biofoundries
Engineered biological systems such as genetic circuits and microbial cell factories have
promised to solve many challenges in the modern society. However, the artisanal processes …
promised to solve many challenges in the modern society. However, the artisanal processes …
SEVA 2.0: an update of the Standard European Vector Architecture for de-/re-construction of bacterial functionalities
Abstract The Standard European Vector Architecture 2.0 database (SEVA-DB 2.0,
http://seva. cnb. csic. es) is an improved and expanded version of the platform released in …
http://seva. cnb. csic. es) is an improved and expanded version of the platform released in …
Sharing structure and function in biological design with SBOL 2.0
The Synthetic Biology Open Language (SBOL) is a standard that enables collaborative
engineering of biological systems across different institutions and tools. SBOL is developed …
engineering of biological systems across different institutions and tools. SBOL is developed …
Tools and applications in synthetic biology
IC MacDonald, TL Deans - Advanced drug delivery reviews, 2016 - Elsevier
Advances in synthetic biology have enabled the engineering of cells with genetic circuits in
order to program cells with new biological behavior, dynamic gene expression, and logic …
order to program cells with new biological behavior, dynamic gene expression, and logic …
Double dutch: a tool for designing combinatorial libraries of biological systems
Recently, semirational approaches that rely on combinatorial assembly of characterized
DNA components have been used to engineer biosynthetic pathways. In practice, however …
DNA components have been used to engineer biosynthetic pathways. In practice, however …
Toward the first data acquisition standard in synthetic biology
This paper describes the development of a new data acquisition standard for synthetic
biology. This comprises the creation of a methodology that is designed to capture all the …
biology. This comprises the creation of a methodology that is designed to capture all the …
A framework for genetic logic synthesis
Digital electronic circuits have inspired synthetic biologists to program living cells with
synthetic decision-making circuits by creating multilevel genetic logic gates. In both genetic …
synthetic decision-making circuits by creating multilevel genetic logic gates. In both genetic …
Generating systems biology markup language models from the synthetic biology open language
In the context of synthetic biology, model generation is the automated process of
constructing biochemical models based on genetic designs. This paper discusses the use …
constructing biochemical models based on genetic designs. This paper discusses the use …
A converter from the systems biology markup language to the synthetic biology open language
Standards are important to synthetic biology because they enable exchange and
reproducibility of genetic designs. This paper describes a procedure for converting between …
reproducibility of genetic designs. This paper describes a procedure for converting between …