Cytochrome P450 enzymes in fungal natural product biosynthesis

X Zhang, J Guo, F Cheng, S Li - Natural Product Reports, 2021 - pubs.rsc.org
Covering: 2015 to the end of 2020 Fungal-derived polyketides, non-ribosomal peptides,
terpenoids and their hybrids contribute significantly to the chemical space of total natural …

Biological activities of meroterpenoids isolated from different sources

NK Fuloria, RK Raheja, KH Shah, MJ Oza… - Frontiers in …, 2022 - frontiersin.org
Meroterpenoids are natural products synthesized by unicellular organisms such as bacteria
and multicellular organisms such as fungi, plants, and animals, including those of marine …

The chemistry and biology of fungal meroterpenoids (2009–2019)

M Jiang, Z Wu, L Liu, S Chen - Organic & Biomolecular Chemistry, 2021 - pubs.rsc.org
Fungal meroterpenoids are secondary metabolites from mixed terpene-biosynthetic origins.
Their intriguing chemical structural diversification and complexity, potential bioactivities, and …

[HTML][HTML] Meroterpenoids: A comprehensive update insight on structural diversity and biology

M Nazir, M Saleem, MI Tousif, MA Anwar, F Surup, I Ali… - Biomolecules, 2021 - mdpi.com
Meroterpenoids are secondary metabolites formed due to mixed biosynthetic pathways
which are produced in part from a terpenoid co-substrate. These mixed biosynthetically …

Enzymatic intermolecular hetero-Diels–Alder reaction in the biosynthesis of tropolonic sesquiterpenes

Q Chen, J Gao, C Jamieson, J Liu… - Journal of the …, 2019 - ACS Publications
Diels–Alder reactions are among the most powerful synthetic transformations to construct
complex natural products. Despite that increasing of enzymatic intramolecular Diels–Alder …

Freshwater fungi as a source of chemical diversity: a review

T El-Elimat, HA Raja, M Figueroa… - Journal of Natural …, 2021 - ACS Publications
As their name indicates, freshwater fungi occur on submerged substrates in fresh water
habitats. This review brings together the chemical diversity and biological activity of 199 of …

Total synthesis and computational investigations of sesquiterpene-tropolones ameliorate stereochemical inconsistencies and resolve an ambiguous biosynthetic …

CY Bemis, CN Ungarean, AS Shved… - Journal of the …, 2021 - ACS Publications
The sesquiterpene-tropolones belong to a distinctive structural class of meroterpene natural
products with impressive biological activities, including anticancer, antifungal, antimalarial …

Dereplication of fungal metabolites by NMR-based compound networking using MADByTE

L Flores-Bocanegra, ZY Al Subeh… - Journal of natural …, 2022 - ACS Publications
Strategies for natural product dereplication are continually evolving, essentially in lock step
with advances in MS and NMR techniques. MADByTE is a new platform designed to identify …

Synthetic biology driven biosynthesis of unnatural tropolone sesquiterpenoids

C Schotte, L Li, D Wibberg… - Angewandte Chemie …, 2020 - Wiley Online Library
Tropolone sesquiterpenoids (TS) are an intriguing family of biologically active fungal
meroterpenoids that arise through a unique intermolecular hetero Diels–Alder (hDA) …

Recent advances in chemistry and antioxidant/anticancer biology of monoterpene and meroterpenoid natural product

BJ Barras, T Ling, F Rivas - Molecules, 2024 - mdpi.com
Monoterpenes and meroterpenes are two large classes of isoprene-based molecules
produced by terrestrial plants and unicellular organisms as diverse secondary metabolites …