BACKGROUND It has long been thought that the factors affecting embryo and foetal
development were exclusively maternally derived; hence, if issues regarding fertility and …

Genomes 5 has been completely revised and updated. It is a thoroughly modern textbook
about genomes and how they are investigated. As with previous Genomes editions …

USH2A mutations are a common cause of autosomal recessive retinitis pigmentosa (RP)
and Usher syndrome, for which there are currently no approved treatments. Gene …

Sperm present a highly particular DNA condensation that is acquired during their
differentiation. Protamines are key elements for DNA condensation. However, whereas the …

Sperm nuclei present a highly organized and condensed chromatin due to the interchange
of histones by protamines during spermiogenesis. This high DNA condensation leads to …

The need of large-scale chromatin organization in the nucleus has become more and more
appreciated. The higher order nuclear organization ultimately regulate a plethora of …

The nuclear matrix, a proteinaceous gel composed of proteins and RNA, is an important
nuclear structure that supports chromatin architecture, but its role in human pluripotent stem …

Background Despite the process of DNA replication being mechanistically highly conserved,
the location of origins of replication (ORI) may vary from one tissue to the next, or between …

In vivo gene delivery involves direct injection of nucleic acids (NAs) into tissues, organs, or
tail-veins. It has been recognized as a useful tool for evaluating the function of a gene of …

The nuclear matrix is a nuclear compartment that has diverse functions in chromatin
regulation and transcription. However, how this structure influences epigenetic modifications …