Despite tremendous successes in the field of antibiotic discovery seen in the previous
century, infectious diseases have remained a leading cause of death. More specifically …

We live in the era of antibiotic resistance, and this problem will progressively worsen if no
new solutions emerge. In particular, Gram-negative pathogens present both biological and …

Antibacterial photodynamic therapy (aPDT) has emerged as a promising strategy for treating
periodontitis. However, the weak binding of most photosensitizers to bacteria and the …

Gram-negative bacteria can resist antibiotics by changing the permeability via their outer
membrane. These bacteria have a complex cell envelope that incorporates an outer …

Synthetic membrane nanopores made of DNA are promising systems to sense and control
molecular transport in biosensing, sequencing, and synthetic cells. Lumen-tunable …

The components and hospitable properties of tumor microenvironment (TME) are associated
with tumor progression. Recently, TME modulating vectors and strategies have garnished …

Gram-negative porins are the main entry for small hydrophilic molecules. We studied
translocation of structurally related cephalosporins, ceftazidime (CAZ), cefotaxime (CTX) and …

Single-entity electrochemistry (SEE) provides powerful means to measure single cells,
single particles, and even single molecules at the nanoscale by diverse well-defined …

Biological nanopores offer a promising approach for single-molecule analysis of nucleic
acids, peptides, and proteins. The work presented here introduces a biological nanopore …

Cell envelope plays a dual role in the life of bacteria by simultaneously protecting it from a
hostile environment and facilitating access to beneficial molecules. At the heart of this ability …