Fungal vacuoles are acidic organelles with degradative and storage capabilities that have
many similarities to mammalian lysosomes and plant vacuoles. In the past several years …

All eukaryotic cells contain multiple acidic organelles, and V-ATPases are central players in
organelle acidification. Not only is the structure of V-ATPases highly conserved among …

Mitochondria have a central role in ageing. They are considered to be both a target of the
ageing process and a contributor to it. Alterations in mitochondrial structure and function are …

Ammonium is an attractive nitrogen form for root uptake due to its permanent availability and
the reduced state of the nitrogen. On the other hand, ammonium fluxes are difficult to control …

The relationship between endosomal pH and function is well documented in viral entry,
endosomal maturation, receptor recycling, and vesicle targeting within the endocytic …

Vacuolar proton-translocating ATPases (V-ATPases) play a central role in organelle
acidification in all eukaryotic cells. To address the role of the yeast V-ATPase in vacuolar …

Despite diverse and changing extracellular environments, fungi maintain a relatively
constant cytosolic pH and numerous organelles of distinct lumenal pH. Key players in fungal …

Cellular aging is a multifactorial process that is characterized by a decline in homeostatic
capacity, best described at the molecular level. Physicochemical properties such as pH and …

We show that the vacuolar protein sorting gene VPS44 is identical to NHX1, a gene that
encodes a sodium/proton exchanger. The Saccharomyces cerevisiae protein Nhx1p shows …

The ammonium transport (Amt) family of proteins comprises a unique and ubiquitous group
of integral membrane proteins found in all domains of life. They are present in bacteria …