Medulloblastoma (MB) comprises a biologically heterogeneous group of embryonal tumours
of the cerebellum. Four subgroups of MB have been described (WNT, sonic hedgehog …

The concept that some childhood malignancies arise from postnatally persistent embryonal
cells has a long history. Recent research has strengthened the links between driver …

Medulloblastoma, a malignant childhood cerebellar tumour, segregates molecularly into
biologically distinct subgroups, suggesting that a personalized approach to therapy would …

Small cell lung carcinoma (SCLC) is a high-grade pulmonary neuroendocrine tumor. The
transcription factors ASCL1 and NEUROD1 play crucial roles in promoting malignant …

Epigenetic alterations, that is, disruption of DNA methylation and chromatin architecture, are
now acknowledged as a universal feature of tumorigenesis. Medulloblastoma, a clinically …

Medulloblastoma (MB) is the most common malignant brain tumor in children and among
the subtypes, Group 3 MB has the worst outcome. Here, we perform an in vivo, patient …

Medulloblastoma, the most common malignant paediatric brain tumour, is currently
diagnosed and stratified using a combination of clinical and demographic variables. Recent …

Complex patterns of cell-type–specific gene expression are thought to be achieved by
combinatorial binding of transcription factors (TFs) to sequence elements in regulatory …

OTX2 is a transcription factor and known driver in medulloblastoma (MB), where it is
amplified in a subset of tumours and overexpressed in most cases of group 3 and group 4 …

Background Canine osteosarcoma is clinically nearly identical to the human disease, but is
common and highly heritable, making genetic dissection feasible. Results Through genome …