Opening doors with ultrasound and microbubbles: Beating biological barriers to promote drug delivery

J Deprez, G Lajoinie, Y Engelen, SC De Smedt… - Advanced drug delivery …, 2021 - Elsevier
Apart from its clinical use in imaging, ultrasound has been thoroughly investigated as a tool
to enhance drug delivery in a wide variety of applications. Therapeutic ultrasound, as such …

[HTML][HTML] Micro/nano-bubble-assisted ultrasound to enhance the EPR effect and potential theranostic applications

L Duan, L Yang, J **, F Yang, D Liu, K Hu, Q Wang… - Theranostics, 2020 - ncbi.nlm.nih.gov
Drug delivery for tumor theranostics involves the extensive use of the enhanced permeability
and retention (EPR) effect. Previously, various types of nanomedicines have been …

[HTML][HTML] Mechanisms underlying sonoporation: Interaction between microbubbles and cells

Y Yang, Q Li, X Guo, J Tu, D Zhang - Ultrasonics Sonochemistry, 2020 - Elsevier
The past several decades have witnessed great progress in “smart drug delivery”, an
advance technology that can deliver genes or drugs into specific locations of patients' body …

[HTML][HTML] Ultrasound-mediated drug delivery: sonoporation mechanisms, biophysics, and critical factors

CH YuAlfred - BME frontiers, 2022 - spj.science.org
Sonoporation, or the use of ultrasound in the presence of cavitation nuclei to induce plasma
membrane perforation, is well considered as an emerging physical approach to facilitate the …

Cell cycle control of nanoplastics internalization in phytoplankton

N Yan, BZ Tang, WX Wang - ACS nano, 2021 - ACS Publications
Nanoparticles (NPs) for delivering chemotherapeutic drugs are now in clinical trials, and
cellular uptake of NPs plays an important role in determining the drug delivery efficiency …

Sonoporation-induced cell membrane permeabilization and cytoskeleton disassembly at varied acoustic and microbubble-cell parameters

M Wang, Y Zhang, C Cai, J Tu, X Guo, D Zhang - Scientific reports, 2018 - nature.com
Sonoporation mediated by microbubbles has being extensively studied as a promising
technique to facilitate gene/drug delivery to cells. Previous studies mainly explored the …

[HTML][HTML] Barrier-breaking effects of ultrasonic cavitation for drug delivery and biomarker release

Y Hu, J Wei, Y Shen, S Chen, X Chen - Ultrasonics Sonochemistry, 2023 - Elsevier
Recently, emerging evidence has demonstrated that cavitation actually creates important
bidirectional channels on biological barriers for both intratumoral drug delivery and …

Ultrasound-responsive materials for drug/gene delivery

X Cai, Y Jiang, M Lin, J Zhang, H Guo, F Yang… - Frontiers in …, 2020 - frontiersin.org
Ultrasound is one of the most commonly used methods in the diagnosis and therapy of
diseases due to its safety, deep penetration into tissue, and non-invasive nature. In the …

Ultrasound-responsive nanocarriers for breast cancer chemotherapy

G Ayana, J Ryu, S Choe - Micromachines, 2022 - mdpi.com
Breast cancer is the most common type of cancer and it is treated with surgical intervention,
radiotherapy, chemotherapy, or a combination of these regimens. Despite chemotherapy's …

Landscape of cellular bioeffects triggered by ultrasound-induced sonoporation

D Przystupski, M Ussowicz - International journal of molecular sciences, 2022 - mdpi.com
Sonoporation is the process of transient pore formation in the cell membrane triggered by
ultrasound (US). Numerous studies have provided us with firm evidence that sonoporation …