After the successful development of antibiotics and the improvement of nutritional and
hygienic conditions, mortalities from infectious diseases have decreased, and chronic …

The calorie restriction paradigm has provided one of the most widely used and most useful
tools for investigating mechanisms of aging and longevity. By far, rodent models have been …

Nutrition science has evolved considerably in the past decade with new concepts and
discoveries. In response, advanced nutrition courses now encompass material on …

Reductions in dietary fat, saturated fat, and cholesterol have been recommended to reduce
the risk of heart disease in our society. The effects of these modifications on human cytokine …

The production of pro-inflammatory cytokines, such as interleukin-1 and tumor necrosis
factor, is pivotal in the response to infection. However, overproduction of these cytokines …

The complex metabolic, vascular and inflammatory perturbations that characterize diabetes
mellitus often lead to progressive albuminuria, renal injury and dysfunction (diabetic …

Cytokines are important biologic mediators with tightly regulated production. Overproduction
contributes to pathogenesis of acute and chronic inflammatory, autoimmune, atherosclerotic …

Calorie restriction (CR) without malnutrition extends life span in several animal models. It
has been proposed that a decrease in the amount of polyunsaturated fatty acids (PUFAs) …

Cytokines and eicosanoids are important biologic mediators with tightly regulated
production. Overproduction contributes to pathogenesis of chronic and acute inflammatory …

Abstract The Membrane Theory of Aging proposes that lifespan is inversely related to the
level of unsaturation in membrane phospholipids. Calorie restriction (CR) without …