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Metformin: A dual-role player in cancer treatment and prevention
MA Galal, M Al-Rimawi, A Hajeer, H Dahman… - International journal of …, 2024 - mdpi.com
Cancer continues to pose a significant global health challenge, as evidenced by the
increasing incidence rates and high mortality rates, despite the advancements made in …
increasing incidence rates and high mortality rates, despite the advancements made in …
Dissecting the dual role of AMPK in cancer: from experimental to human studies
G Zadra, JL Batista, M Loda - Molecular cancer research, 2015 - aacrjournals.org
The precise role of 5′ AMP-activated kinase (AMPK) in cancer and its potential as a
therapeutic target is controversial. Although it is well established that activation of this …
therapeutic target is controversial. Although it is well established that activation of this …
Metformin and risk of cancer among patients with type 2 diabetes mellitus: A systematic review and meta-analysis
K Zhang, P Bai, H Dai, Z Deng - Primary care diabetes, 2021 - Elsevier
Aim We carried out this meta-analysis on all published studies to estimate the overall cancer
risk of the use of metformin in T2DM patients. Methods We searched the PubMed, Embase …
risk of the use of metformin in T2DM patients. Methods We searched the PubMed, Embase …
Chemotherapy targeting cancer stem cells
H Liu, L Lv, K Yang - American journal of cancer research, 2015 - pmc.ncbi.nlm.nih.gov
Conventional chemotherapy is the main treatment for cancer and benefits patients in the
form of decreased relapse and metastasis and longer overall survival. However, as the …
form of decreased relapse and metastasis and longer overall survival. However, as the …
Risk of gastric cancer development after eradication of Helicobacter pylori
Helicobacter pylori (H. pylori) infection is the most important risk factor for gastric cancer
(GC) development through the Correa's gastric carcinogenesis cascade. However, H. pylori …
(GC) development through the Correa's gastric carcinogenesis cascade. However, H. pylori …
Metformin Use and Gastric Cancer Risk in Diabetic Patients After Helicobacter pylori Eradication
Background Although prior studies showed metformin could reduce gastric cancer (GC) risk
in patients with diabetes mellitus, they failed to adjust for Helicobacter pylori infection and …
in patients with diabetes mellitus, they failed to adjust for Helicobacter pylori infection and …
Repurposing metformin for the treatment of gastrointestinal cancer
Diabetes mellitus type 2 and cancer share many risk factors. The pleiotropic insulin-
dependent and insulin-independent effects of metformin might inhibit pathways that are …
dependent and insulin-independent effects of metformin might inhibit pathways that are …
Metformin reduces gastric cancer risk in patients with type 2 diabetes mellitus
This retrospective cohort study investigated whether metformin may reduce gastric cancer
risk by using the reimbursement databases of the Taiwan's National Health Insurance …
risk by using the reimbursement databases of the Taiwan's National Health Insurance …
Metformin-induced anticancer activities: recent insights
Metformin is a widely used antidiabetic drug, and there is evidence among diabetic patients
that metformin is a chemopreventive agent against multiple cancers. There is also evidence …
that metformin is a chemopreventive agent against multiple cancers. There is also evidence …
Metformin reduces the risk of cancer in patients with type 2 diabetes: An analysis based on the Korean National Diabetes Program Cohort
The epidemiological literature suggests that insulin resistance, hyperinsulinemia, and
increased levels of insulin-like growth factors place patients with type 2 diabetes mellitus …
increased levels of insulin-like growth factors place patients with type 2 diabetes mellitus …