In the non‐amyloidogenic pathway, the Alzheimer's amyloid precursor protein (APP) is
cleaved within the amyloid‐β domain by α‐secretase precluding deposition of intact amyloid …

The amyloid β-peptide (Aβ) is a principal component of the cerebral plaques found in the
brains of patients with Alzeheimer's disease (AD). This insoluble 40–to 42–amino acid …

It has long been assumed that the C-terminal motif, NPXY, is the internalization signal for β-
amyloid precursor protein (APP) and that the NPXY tyrosine (Tyr 743 by APP751 numbering …

Green tea extract and its main polyphenol constituent (‐)‐epigallocatechin‐3‐gallate
(EGCG) possess potent neuroprotective activity in cell culture and mice model of Parkinson's …

During the first 100 years of Alzheimer's disease research, this devastating and intractable
disorder has been characterized at the clinical, histological, and molecular levels …

ADAM10, a member of a disintegrin and metalloprotease family, is an α-secretase capable
of anti-amyloidogenic proteolysis of the amyloid precursor protein. Here, we present …

The β-amyloid precursor protein (APP) is proteolytically processed to generate β-amyloid
protein, the principal protein component of neuropathological lesions characteristic of …

Immunostaining of adenosine receptors in the hippocampus and cerebral cortex from
necropsies of Alzheimer's disease (AD) patients shows that there is a change in the pattern …

Amyloid βprotein, the principal constituent of amyloid fibrils found in senile plaques and
blood vessels in Alzheimer's disease, is constitutively produced and released into medium …

The reduction in levels of the potentially toxic amyloid-β peptide (Aβ) has emerged as one of
the most important therapeutic goals in Alzheimer's disease. Key targets for this goal are …