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Impaired insulin signalling and allostatic load in Alzheimer disease
FG De Felice, RA Gonçalves, ST Ferreira - Nature Reviews …, 2022 - nature.com
The discovery of insulin in 1921 revolutionized the treatment of diabetes and paved the way
for numerous studies on hormone signalling networks and actions in peripheral tissues and …
for numerous studies on hormone signalling networks and actions in peripheral tissues and …
[HTML][HTML] Free fatty acid receptors in health and disease
I Kimura, A Ichimura, R Ohue-Kitano… - Physiological …, 2019 - journals.physiology.org
Fatty acids are metabolized and synthesized as energy substrates during biological
responses. Long-and medium-chain fatty acids derived mainly from dietary triglycerides, and …
responses. Long-and medium-chain fatty acids derived mainly from dietary triglycerides, and …
Arcuate nucleus-dependent regulation of metabolism—pathways to obesity and diabetes mellitus
A Jais, JC Brüning - Endocrine reviews, 2022 - academic.oup.com
The central nervous system (CNS) receives information from afferent neurons, circulating
hormones, and absorbed nutrients and integrates this information to orchestrate the actions …
hormones, and absorbed nutrients and integrates this information to orchestrate the actions …
Effect of high-fat diets on oxidative stress, cellular inflammatory response and cognitive function
BL Tan, ME Norhaizan - Nutrients, 2019 - mdpi.com
Cognitive dysfunction is linked to chronic low-grade inflammatory stress that contributes to
cell-mediated immunity in creating an oxidative environment. Food is a vitally important …
cell-mediated immunity in creating an oxidative environment. Food is a vitally important …
Obesity, inflammation, toll-like receptor 4 and fatty acids
Obesity leads to an inflammatory condition that is directly involved in the etiology of
cardiovascular diseases, type 2 diabetes mellitus, and certain types of cancer. The classic …
cardiovascular diseases, type 2 diabetes mellitus, and certain types of cancer. The classic …
Inflammatory links between high fat diets and diseases
Y Duan, L Zeng, C Zheng, B Song, F Li… - Frontiers in …, 2018 - frontiersin.org
In recent years, chronic overnutrition, such as consumption of a high-fat diet (HFD), has
been increasingly viewed as a significant modifiable risk factor for diseases such as …
been increasingly viewed as a significant modifiable risk factor for diseases such as …
Determinants of obesity in Latin America
SRG Ferreira, Y Macotela, LA Velloso, MA Mori - Nature metabolism, 2024 - nature.com
Obesity rates are increasing almost everywhere in the world, although the pace and timing
for this increase differ when populations from developed and develo** countries are …
for this increase differ when populations from developed and develo** countries are …
Obesity as a disease
J Upadhyay, O Farr, N Perakakis, W Ghaly… - Medical …, 2018 - medical.theclinics.com
Obesity is a complex, chronic medical condition with a major negative impact on human
health. 1 Over the last 30 years, there has been an exponential growth in the prevalence of …
health. 1 Over the last 30 years, there has been an exponential growth in the prevalence of …
[HTML][HTML] Malnutrition in obesity: is it possible?
M Kobylińska, K Antosik, A Decyk, K Kurowska - Obesity Facts, 2022 - karger.com
Background: The World Health Organization (WHO) classifies malnutrition as the biggest
threat to public health worldwide, and this condition is observed in 20–60% of hospitalized …
threat to public health worldwide, and this condition is observed in 20–60% of hospitalized …
AgRP/NPY and POMC neurons in the arcuate nucleus and their potential role in treatment of obesity
MS Vohra, K Benchoula, CJ Serpell, WE Hwa - European journal of …, 2022 - Elsevier
Obesity is a major health crisis affecting over a third of the global population. This
multifactorial disease is regulated via interoceptive neural circuits in the brain, whose …
multifactorial disease is regulated via interoceptive neural circuits in the brain, whose …