In the present review, we deliver an overview of the involvement of metabotropic glutamate
receptor 5 (mGluR5) activity and density in pathological anxiety, mood disorders and …

The metabotropic glutamatergic receptor subtype 5 (mGluR5) may represent a promising
therapeutic target for stress-related psychiatric disorders. Here, we describe mGluR5 …

Purpose Metabotropic glutamate receptor type 5 (mGluR5) is a G protein-coupled receptor
that has been implicated in several psychiatric and neurological diseases. The …

Animal models indicate that the endocannabinoid system (ECS) plays a modulatory role in
stress and reward processing, both crucially impaired in addictive disorders. Preclinical …

Background Preclinical studies demonstrate that glutamate homeostasis in the striatum is
disrupted following cocaine exposure, including a decrease in metabotropic glutamate …

Cocaine self-administration decreases type 5 metabotropic glutamate receptor (mGluR5)
tissue concentrations in laboratory rats during early abstinence. These changes are thought …

Background Enhanced drug-related reward sensitivity accompanied by impaired sensitivity
to non-drug related rewards in the mesolimbic dopamine system are thought to underlie the …

Consistent findings postulate disturbed glutamatergic function (more specifically a
hypofunction of the ionotropic NMDA receptors) as an important pathophysiologic …

Background: Abundant evidence at the anatomical, electrophysiological, and molecular
levels implicates metabotropic glutamate receptor subtype 5 (mGluR5) in addiction …

Drug addiction is characterized by widespread abnormalities in brain function and
neurochemistry, including drug-associated effects on concentrations of the excitatory and …