Errors occurring during DNA replication can result in inaccurate replication, incomplete
replication, or re-replication, resulting in genome instability that can lead to diseases such as …

The accurate and complete replication of genomic DNA is essential for all life. In eukaryotic
cells, the assembly of the multi-enzyme replisomes that perform replication is divided into …

During eukaryotic DNA replication, Pol α-primase generates primers at replication origins to
start leading-strand synthesis and every few hundred nucleotides during discontinuous …

Chromosome replication is performed by a complex and intricate ensemble of proteins
termed the replisome, where the DNA polymerases Polδ and Polε, DNA polymerase α …

The eukaryotic replisome is a molecular machine that coordinates the Cdc45-MCM-GINS
(CMG) replicative DNA helicase with DNA polymerases α, δ, and ε and other proteins to …

The human replisome is an elaborate arrangement of molecular machines responsible for
accurate chromosome replication. At its heart is the CDC45‐MCM‐GINS (CMG) helicase …

Mutational processes constantly shape the somatic genome, leading to immunity, aging,
cancer, and other diseases. When cancer is the outcome, we are afforded a glimpse into …

Although it has long been recognized that the exonucleolytic proofreading activity intrinsic to
the replicative DNA polymerases Pol δ and Pol ε is essential for faithful replication of DNA …

Proliferating cell nuclear antigen (PCNA) plays critical roles in many aspects of DNA
replication and replication-associated processes, including translesion synthesis, error-free …

A role for somatic mutations in carcinogenesis is well accepted, but the degree to which
mutation rates influence cancer initiation and development is under continuous debate …