The semantics of microglia activation: neuroinflammation, homeostasis, and stress

SC Woodburn, JL Bollinger, ES Wohleb - Journal of neuroinflammation, 2021 - Springer
Microglia are emerging as critical regulators of neuronal function and behavior in nearly
every area of neuroscience. Initial reports focused on classical immune functions of …

Long-lasting effects of prenatal stress on HPA axis and inflammation: a systematic review and multilevel meta-analysis in rodent studies

KC Creutzberg, A Sanson, TW Viola… - Neuroscience & …, 2021 - Elsevier
Exposure to prenatal stress (PNS) can lead to long-lasting neurobiological and behavioral
consequences for the offspring, which may enhance the susceptibility for mental disorders …

Dysfunctional serotonergic neuron-astrocyte signaling in depressive-like states

C González-Arias, A Sánchez-Ruiz, J Esparza… - Molecular …, 2023 - nature.com
Astrocytes play crucial roles in brain homeostasis and are regulatory elements of neuronal
and synaptic physiology. Astrocytic alterations have been found in Major Depressive …

Relationship between depression and olfactory sensory function: a review

A Athanassi, R Dorado Doncel, KG Bath… - Chemical …, 2021 - academic.oup.com
Links between olfactory sensory function and effect have been well established. A robust
literature exists in both humans and animals showing that disrupting olfaction sensory …

Advancing preclinical chronic stress models to promote therapeutic discovery for human stress disorders

TM Gyles, EJ Nestler, EM Parise - Neuropsychopharmacology, 2024 - nature.com
There is an urgent need to develop more effective treatments for stress-related illnesses,
which include depression, post-traumatic stress disorder, and anxiety. We view animal …

Organic cation transporters in psychiatric and substance use disorders

LE Honan, R Fraser-Spears, LC Daws - Pharmacology & therapeutics, 2024 - Elsevier
Psychiatric and substance use disorders inflict major public health burdens worldwide. Their
widespread burden is compounded by a dearth of effective treatments, underscoring a dire …

Experience-dependent information routing through the basolateral amygdala shapes behavioral outcomes

P Antonoudiou, BT Stone, PLW Colmers… - Cell reports, 2024 - cell.com
It is well established that the basolateral amygdala (BLA) is an emotional processing hub
that governs a diverse repertoire of behaviors. Selective engagement of a heterogeneous …

Chronic non-discriminatory social defeat stress reduces effort-related motivated behaviors in male and female mice

A Dieterich, T Liu, BA Samuels - Translational psychiatry, 2021 - nature.com
Reward and motivation deficits are prominent symptoms in many mood disorders, including
depression. Similar reward and effort-related choice behavioral tasks can be used to study …

Pharmacological characterisation of the effort for reward task as a measure of motivation for reward in male mice

C Marangoni, M Tam, ESJ Robinson, MG Jackson - Psychopharmacology, 2023 - Springer
Rationale Motivational deficits are a common symptom shared across multiple psychiatric
and neurodegenerative disorders. Effort-based decision-making tasks are a translatable …

Neuromolecular underpinnings of negative cognitive bias in depression

K Noworyta, A Cieslik, R Rygula - Cells, 2021 - mdpi.com
This selective review aims to summarize the recent advances in understanding the
neuromolecular underpinnings of biased cognition in depressive disorder. We begin by …