The semantics of microglia activation: neuroinflammation, homeostasis, and stress
Microglia are emerging as critical regulators of neuronal function and behavior in nearly
every area of neuroscience. Initial reports focused on classical immune functions of …
every area of neuroscience. Initial reports focused on classical immune functions of …
Long-lasting effects of prenatal stress on HPA axis and inflammation: a systematic review and multilevel meta-analysis in rodent studies
Exposure to prenatal stress (PNS) can lead to long-lasting neurobiological and behavioral
consequences for the offspring, which may enhance the susceptibility for mental disorders …
consequences for the offspring, which may enhance the susceptibility for mental disorders …
Dysfunctional serotonergic neuron-astrocyte signaling in depressive-like states
C González-Arias, A Sánchez-Ruiz, J Esparza… - Molecular …, 2023 - nature.com
Astrocytes play crucial roles in brain homeostasis and are regulatory elements of neuronal
and synaptic physiology. Astrocytic alterations have been found in Major Depressive …
and synaptic physiology. Astrocytic alterations have been found in Major Depressive …
Relationship between depression and olfactory sensory function: a review
A Athanassi, R Dorado Doncel, KG Bath… - Chemical …, 2021 - academic.oup.com
Links between olfactory sensory function and effect have been well established. A robust
literature exists in both humans and animals showing that disrupting olfaction sensory …
literature exists in both humans and animals showing that disrupting olfaction sensory …
Advancing preclinical chronic stress models to promote therapeutic discovery for human stress disorders
There is an urgent need to develop more effective treatments for stress-related illnesses,
which include depression, post-traumatic stress disorder, and anxiety. We view animal …
which include depression, post-traumatic stress disorder, and anxiety. We view animal …
Organic cation transporters in psychiatric and substance use disorders
LE Honan, R Fraser-Spears, LC Daws - Pharmacology & therapeutics, 2024 - Elsevier
Psychiatric and substance use disorders inflict major public health burdens worldwide. Their
widespread burden is compounded by a dearth of effective treatments, underscoring a dire …
widespread burden is compounded by a dearth of effective treatments, underscoring a dire …
Experience-dependent information routing through the basolateral amygdala shapes behavioral outcomes
It is well established that the basolateral amygdala (BLA) is an emotional processing hub
that governs a diverse repertoire of behaviors. Selective engagement of a heterogeneous …
that governs a diverse repertoire of behaviors. Selective engagement of a heterogeneous …
Chronic non-discriminatory social defeat stress reduces effort-related motivated behaviors in male and female mice
A Dieterich, T Liu, BA Samuels - Translational psychiatry, 2021 - nature.com
Reward and motivation deficits are prominent symptoms in many mood disorders, including
depression. Similar reward and effort-related choice behavioral tasks can be used to study …
depression. Similar reward and effort-related choice behavioral tasks can be used to study …
Pharmacological characterisation of the effort for reward task as a measure of motivation for reward in male mice
C Marangoni, M Tam, ESJ Robinson, MG Jackson - Psychopharmacology, 2023 - Springer
Rationale Motivational deficits are a common symptom shared across multiple psychiatric
and neurodegenerative disorders. Effort-based decision-making tasks are a translatable …
and neurodegenerative disorders. Effort-based decision-making tasks are a translatable …
Neuromolecular underpinnings of negative cognitive bias in depression
This selective review aims to summarize the recent advances in understanding the
neuromolecular underpinnings of biased cognition in depressive disorder. We begin by …
neuromolecular underpinnings of biased cognition in depressive disorder. We begin by …