Mass-spectrometry-based proteomic analysis is a powerful approach for discovering new
disease biomarkers. However, certain critical steps of study design such as cohort selection …

A biological marker (biomarker) is a substance used as an indicator of biological state.
Advances in genomics, proteomics and molecular pathology have generated many …

Discovering the gene expression signature associated with a cellular state is one of the
basic quests in majority of biological studies. For most of the clinical and cellular …

Nuclear-retained long non-coding RNAs (lncRNAs) including MALAT1 have emerged as
critical regulators of many molecular processes including transcription, alternative splicing …

Plasma and serum are widely used for proteomics-based biomarker discovery. However,
analysis of these biofluids is highly challenging due to the complexity and wide dynamic …

Over the past decades, the proteomics field has undergone rapid growth. Progress in mass
spectrometry and bioinformatics, together with separation methods, has brought many …

A cell integrates various signals through a network of biomolecules that crosstalk to
synergistically regulate the replication, transcription, translation and other metabolic …

Proteogenomics refers to the integrated analysis of the genome and proteome that
leverages mass-spectrometry (MS)-based proteomics data to improve genome annotations …

Cells secrete a large number of proteins to communicate with their surroundings.
Furthermore, plasma membrane proteins and intracellular proteins can be released into the …

BACKGROUND Novel biomarkers to identify infectious patients transmitting Mycobacterium
tuberculosis are urgently needed to control the global tuberculosis (TB) pandemic. We …