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Shared and distinct mechanisms of fibrosis
Fibrosis is defined as an excessive deposition of connective tissue components and can
affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue …
affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue …
Idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis is a prototype of chronic, progressive, and fibrotic lung disease.
Healthy tissue is replaced by altered extracellular matrix and alveolar architecture is …
Healthy tissue is replaced by altered extracellular matrix and alveolar architecture is …
Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis
Pulmonary fibrosis (PF) is a form of chronic lung disease characterized by pathologic
epithelial remodeling and accumulation of extracellular matrix (ECM). To comprehensively …
epithelial remodeling and accumulation of extracellular matrix (ECM). To comprehensively …
Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage
Tissue fibrosis is a major cause of mortality that results from the deposition of matrix proteins
by an activated mesenchyme. Macrophages accumulate in fibrosis, but the role of specific …
by an activated mesenchyme. Macrophages accumulate in fibrosis, but the role of specific …
SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in mice
A subset of individuals who recover from coronavirus disease 2019 (COVID-19) develop
post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study
Background Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with
high mortality, uncertain cause, and few treatment options. Studies have identified a …
high mortality, uncertain cause, and few treatment options. Studies have identified a …
Mitochondrial NADP (H) generation is essential for proline biosynthesis
The coenzyme nicotinamide adenine dinucleotide phosphate (NADP+) and its reduced form
(NADPH) regulate reductive metabolism in a subcellularly compartmentalized manner …
(NADPH) regulate reductive metabolism in a subcellularly compartmentalized manner …
Cilia dysfunction in lung disease
A characteristic feature of the human airway epithelium is the presence of ciliated cells
bearing motile cilia, specialized cell surface projections containing axonemes composed of …
bearing motile cilia, specialized cell surface projections containing axonemes composed of …
An epithelial biomarker signature for idiopathic pulmonary fibrosis: an analysis from the multicentre PROFILE cohort study
Background Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disorder with a
variable disease trajectory. The aim of this study was to assess potential biomarkers to …
variable disease trajectory. The aim of this study was to assess potential biomarkers to …
Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice
The gain-of-function MUC5B promoter variant rs35705950 is the dominant risk factor for
develo** idiopathic pulmonary fibrosis (IPF). Here we show in humans that MUC5B, a …
develo** idiopathic pulmonary fibrosis (IPF). Here we show in humans that MUC5B, a …