Follicular helper T (TFH) cells provide help to B cells, supporting the formation of germinal
centres that allow affinity maturation of antibody responses. Although usually located in …

BACKGROUND The mammalian immune system is a remarkable sensory system for the
detection and neutralization of pathogens. History is replete with the devastating effects of …

Obesity is associated with an increased risk of severe Coronavirus Disease 2019 (COVID-
19) infection and mortality. COVID-19 vaccines reduce the risk of serious COVID-19 …

Highly effective vaccines elicit specific, robust, and durable adaptive immune responses. To
advance informed vaccine design, it is critical that we understand the cellular dynamics …

Pediatric coronavirus disease 2019 (COVID-19) after SARS-CoV-2 infection is associated
with fewer hospitalizations and often milder disease than in adults. A subset of children …

SARS-CoV-2 causes a spectrum of COVID-19 disease, the immunological basis of which
remains ill defined. We analyzed 85 SARS-CoV-2-infected individuals at acute and/or …

T follicular helper (Tfh) cells cognately guide differentiation of antigen-primed B cells in
secondary lymphoid tissues.'Tfh-like'populations not expressing the canonical Tfh cell …

Emulsion adjuvants such as MF59 and AS03 have been used for more than two decades as
key components of licensed vaccines, with over 100 million doses administered to diverse …

Surgical resection remains the mainstay treatment for solid cancers, especially for localized
disease. However, the postoperative immunosuppression provides a window for cancer cell …

CD4+ memory T cells play an important role in protective immunity and are a key target in
vaccine development. Many studies have focused on T central memory (Tcm) cells, whereas …