Consanguineous marriages have been practiced since the early existence of modern
humans. Until now consanguinity is widely practiced in several global communities with …

There is little information on inbreeding during the critical early years of human existence.
However, given the small founding group sizes and restricted mate choices it seems …

Background Traditional genetic testing focusses on analysis of one or a few genes
according to clinical features; this approach is changing as improved sequencing methods …

Intellectual disability (ID) is the leading socio-economic problem of health care, but
compared to autism and schizophrenia, it has received very little public attention. Important …

Technological and other advances over the past decades have led to the discovery of
thousands of gene–disease associations for autosomal and X-linked recessive Mendelian …

Consanguineous marriages, where spouses are related by blood, have been a
longstanding practice in human history. The primary medical concern with consanguineous …

Most severe forms of intellectual disability (ID) have specific genetic causes. Numerous X
chromosome gene defects and disease-causing copy-number variants have been linked to …

The 10 warning signs of primary immunodeficiency are being promoted as a screening tool
for use by both the general public and physicians. A recent study, however, shows that …

North Africa is defined as the geographical region separated from the rest of the continent by
the Sahara and from Europe by the Mediterranean Sea. The main demographic features of …

Marriage between biological relatives is widely popular in many parts of the world, with over
1000million people living in countries where 20–50+% of unions are contracted between …