The cyclin-dependent kinase inhibitor p21WAF1/CIP1 is a major player in cell cycle control
and it is mainly regulated at the transcriptional level. Whereas induction of p21 …

Small heterodimer partner (SHP, NR0B2) is a unique member of the nuclear receptor (NR)
superfamily that contains the dimerization and ligand-binding domain found in other family …

Cell state changes are associated with proteome remodeling to serve newly emergent cell
functions. Here, we show that NGN2-driven conversion of human embryonic stem cells to …

Production and secretion of insulin from the β-cells of the pancreas is very crucial in
maintaining normoglycaemia. This is achieved by tight regulation of insulin synthesis and …

Drugs and bile acids are taken up into hepatocytes by specialized transport proteins
localized at the basolateral membrane, eg, organic anion transporting polypeptides …

The principle factors underlying gastric cancer (GC) development and outcomes are not well
characterized resulting in a paucity of validated therapeutic targets. To identify potential …

Orphan nuclear receptor small heterodimer partner (SHP) plays a key role in transcriptional
repression of gluconeogenic enzyme gene expression. Here, we show that SHP inhibited …

Small bowel vascular malformation disease (SBVM) commonly causes obscure
gastrointestinal bleeding (OGIB). However, the pathogenetic mechanism and the role of …

The nuclear receptor superfamily includes many receptors, identified based on their
similarity to steroid hormone receptors but without a known ligand. The study of how these …

Type 2 diabetes is primarily associated with insulin resistance and β-cell dysfunction.
Maintenance of functional mature β-cells is imperative for ensuring glucose homeostasis …