Liquid chromatography–mass spectrometry (LC–MS)-based untargeted metabolomics is
constantly challenged by large-scale and unambiguous metabolite annotation in complex …

Technological innovations have transformed the way scientists approach biological and
clinical questions, transiting from conventional ensemble assays in bulk to emphasize on the …

Dysregulated glycerophospholipid (GP) metabolism in the brain is associated with the
progression of neurodegenerative diseases including Alzheimer's disease (AD). Routine …

Ion mobility-mass spectrometry (IM-MS) is a powerful separation technique providing an
additional dimension of separation to support the enhanced separation and characterization …

Omics studies such as metabolomics, lipidomics, and proteomics have become important for
understanding the mechanisms in living organisms. However, the compounds detected are …

Metabolomics samples like human urine or serum contain upwards of a few thousand
metabolites, but individual analytical techniques can only characterize a few hundred …

Biological processes unfold across broad spatial and temporal dimensions, and
measurement of the underlying molecular world is essential to their understanding …

Background Lipidomics studies require rapid separations with accurate and reliable
quantification results to further elucidate the role of lipids in biological processes and their …

Collision cross sections (CCS) have been described as relevant molecular descriptors in
metabolomics and lipidomics analyses for ascertaining compound identity. Ion mobility …

Aberrant lipid metabolism has been widely recognized as a hallmark of various diseases.
However, the comprehensive analysis of distinct lipids is challenging due to the complexity …