Inflammation is an underlying feature of a variety of human diseases. An important
manifestation of this pathophysiological response is microvascular dysfunction, which …

Glaucoma, one of the major causes of blindness in the world, is a progressive optic
neuropathy. Elevated intraocular pressure is a well‐known major risk factor for glaucoma. In …

Glaucomatous optic neuropathy implies loss of neural tissue, activation of glial cells, tissue
remodeling, and change of blood flow. The blood flow reduction is not only secondary but …

Objective: Recent findings indicate that platelets not only regulate thrombosis and
hemostasis but may also be involved in proinflammatory activities. Herein, we hypothesized …

Rationale: Delivery of therapeutic agents to the brain is limited by the presence of the blood-
brain barrier (BBB). An emerging strategy to temporarily and locally increase the …

Clinical and experimental evidence indicate that increased vascular permeability contributes
to many disease-associated vascular complications. Oxidative stress with increased …

Objective: To define the role of CD40L in abdominal sepsis. Background: Platelets promote
sepsis-induced pulmonary recruitment of neutrophils. However, the identity of the platelet …

The lungs provide a large inner surface to guarantee respiration. In lung alveoli, a delicate
membrane formed by endo-and epithelial cells with their fused basal lamina ensures rapid …

In response to infections or tissue injury, circulating leucocytes adhere to and migrate from
the vessel lumen to interstitial inflammatory sites to combat invading pathogens. However …

Exposure to fine particulate matter (PM, mean aerodynamic diameter≤ 2.5 μm) has been
shown to be a risk factor for cardiovascular disease mortality and may contribute to acute …