Eukaryotic cell size regulation and its implications for cellular function and dysfunction
Y Chadha, A Khurana… - Physiological …, 2024 - journals.physiology.org
Depending on cell type, environmental inputs, and disease, the cells in the human body can
have widely different sizes. In recent years, it has become clear that cell size is a major …
have widely different sizes. In recent years, it has become clear that cell size is a major …
Colloquium: Gene expression in growing cells: A biophysical primer
I Golding, A Amir - Reviews of Modern Physics, 2024 - APS
Cell growth and gene expression, two essential elements of all living systems, have long
been the focus of biophysical interrogation. Advances in experimental single-cell methods …
been the focus of biophysical interrogation. Advances in experimental single-cell methods …
Matrix stiffness drives drop like nuclear deformation and lamin A/C tension-dependent YAP nuclear localization
Extracellular matrix (ECM) stiffness influences cancer cell fate by altering gene expression.
Previous studies suggest that stiffness-induced nuclear deformation may regulate gene …
Previous studies suggest that stiffness-induced nuclear deformation may regulate gene …
Amino acids modulate liquid–liquid phase separation in vitro and in vivo by regulating protein–protein interactions
Liquid–liquid phase separation (LLPS) is an intracellular process widely used by cells for
many key biological functions. It occurs in complex and crowded environments, where …
many key biological functions. It occurs in complex and crowded environments, where …
N2FXm, a method for joint nuclear and cytoplasmic volume measurements, unravels the osmo-mechanical regulation of nuclear volume in mammalian cells
In eukaryotes, cytoplasmic and nuclear volumes are tightly regulated to ensure proper cell
homeostasis. However, current methods to measure cytoplasmic and nuclear volumes …
homeostasis. However, current methods to measure cytoplasmic and nuclear volumes …
Physiological stress drives the emergence of a Salmonella subpopulation through ribosomal RNA regulation
Bacteria undergo cycles of growth and starvation to which they must adapt swiftly. One
important strategy for adjusting growth rates relies on ribosomal levels. Although high …
important strategy for adjusting growth rates relies on ribosomal levels. Although high …
The thermoneutral zone in women takes an “arctic” shift compared to men
RJ Brychta, S McGehee, S Huang… - Proceedings of the …, 2024 - National Acad Sciences
Conventionally, women are perceived to feel colder than men, but controlled comparisons
are sparse. We measured the response of healthy, lean, young women and men to a range …
are sparse. We measured the response of healthy, lean, young women and men to a range …
Confinement-sensitive volume regulation dynamics via high-speed nuclear morphological measurements
Diverse tissues in vivo present varying degrees of confinement, constriction, and
compression to migrating cells in both homeostasis and disease. The nucleus in particular is …
compression to migrating cells in both homeostasis and disease. The nucleus in particular is …
[HTML][HTML] Cytoskeletal activation of NHE1 regulates mechanosensitive cell volume adaptation and proliferation
Mammalian cells rapidly respond to environmental changes by altering transmembrane
water and ion fluxes, changing cell volume. Contractile forces generated by actomyosin …
water and ion fluxes, changing cell volume. Contractile forces generated by actomyosin …
Survival dynamics of starving bacteria are determined by ion homeostasis that maintains plasmolysis
The ability to survive starvation is an integral part of bacterial fitness and determines
composition, turnover and biodiversity in microbial ecosystems. Starving bacteria enter a …
composition, turnover and biodiversity in microbial ecosystems. Starving bacteria enter a …