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[HTML][HTML] Cancer stem cells: the architects of the tumor ecosystem
Cancer stem cells (CSCs) proactively remodel their microenvironment to maintain a
supportive niche. Viewed through the lens of an ecosystem, numerous tumor components …
supportive niche. Viewed through the lens of an ecosystem, numerous tumor components …
Impact of the physical microenvironment on tumor progression and metastasis
Highlights•Physical cues from the tumor microenvironment strongly affect cancer cell
behavior.•Novel techniques increasingly help to capture those cues in vitro.•Mechanisms for …
behavior.•Novel techniques increasingly help to capture those cues in vitro.•Mechanisms for …
[HTML][HTML] Circulating tumor cell technologies
Circulating tumor cells, a component of the “liquid biopsy”, hold great potential to transform
the current landscape of cancer therapy. A key challenge to unlocking the clinical utility of …
the current landscape of cancer therapy. A key challenge to unlocking the clinical utility of …
Single-cell RNA-seq: advances and future challenges
Phenotypically identical cells can dramatically vary with respect to behavior during their
lifespan and this variation is reflected in their molecular composition such as the …
lifespan and this variation is reflected in their molecular composition such as the …
Mechanical adaptability of tumor cells in metastasis
The most dangerous aspect of cancer lies in metastatic progression. Tumor cells will
successfully form life-threatening metastases when they undergo sequential steps along a …
successfully form life-threatening metastases when they undergo sequential steps along a …
Microfluidics: reframing biological enquiry
The underlying physical properties of microfluidic tools have led to new biological insights
through the development of microsystems that can manipulate, mimic and measure biology …
through the development of microsystems that can manipulate, mimic and measure biology …
[HTML][HTML] Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform
Cardiomyocytes from human pluripotent stem cells (hPSCs-CMs) could revolutionise
biomedicine. Global burden of heart failure will soon reach USD $90 bn, while unexpected …
biomedicine. Global burden of heart failure will soon reach USD $90 bn, while unexpected …
Cancer stem cell plasticity–a deadly deal
Intratumoral heterogeneity is a major ongoing challenge in the effective therapeutic targeting
of cancer. Accumulating evidence suggests that a fraction of cells within a tumor termed …
of cancer. Accumulating evidence suggests that a fraction of cells within a tumor termed …
Dual-responsive surfaces modified with phenylboronic acid-containing polymer brush to reversibly capture and release cancer cells
Artificial stimuli-responsive surfaces that can mimic the dynamic function of living systems
have attracted much attention. However, there exist few artificial systems capable of …
have attracted much attention. However, there exist few artificial systems capable of …
Homeostatic membrane tension constrains cancer cell dissemination by counteracting BAR protein assembly
K Tsujita, R Satow, S Asada, Y Nakamura… - Nature …, 2021 - nature.com
Malignancy is associated with changes in cell mechanics that contribute to extensive cell
deformation required for metastatic dissemination. We hypothesized that the cell-intrinsic …
deformation required for metastatic dissemination. We hypothesized that the cell-intrinsic …