Aging is a major risk factor for a number of chronic diseases, including neurodegenerative
and cerebrovascular disorders. Aging processes have therefore been discussed as potential …

The process of senescence (aging) is predominantly determined by the action of wild-type
genes. For most organisms, this does not reflect any adaptive function that senescence …

Aging clocks dissociate biological from chronological age. The estimation of biological age
is important for identifying gerontogenes and assessing environmental, nutritional, or …

Aging (senescence) is characterized by the development of numerous pathologies, some of
which limit lifespan. Key to understanding aging is discovery of the mechanisms (etiologies) …

Caenorhabditis elegans is an exceptionally valuable model for aging research because of
many advantages, including its genetic tractability, short lifespan, and clear age‐dependent …

Understanding how the human gut microbiota might influence ageing is challenging. The
gut microbiota is a hugely complex ecology of organisms that varies greatly with individuals …

In post-reproductive C. elegans, destructive somatic biomass repurposing supports
production of yolk which, it was recently shown, is vented and can serve as a foodstuff for …

Dietary restriction (DR) has long been viewed as the most robust nongenetic means to
extend lifespan and healthspan. Many aging-associated mechanisms are nutrient …

Cells have evolved complex mechanisms to maintain protein homeostasis, such as the UPR
ER, which are strongly associated with several diseases and the aging process. We …

During aging, proteostasis capacity declines and distinct proteins become unstable and can
accumulate as protein aggregates inside and outside of cells. Both in disease and during …