Senescence mechanisms and targets in the heart
Cellular senescence is a state of irreversible cell cycle arrest associated with ageing.
Senescence of different cardiac cell types can direct the pathophysiology of cardiovascular …
Senescence of different cardiac cell types can direct the pathophysiology of cardiovascular …
Innate and adaptive immunity: the understudied driving force of heart valve disease
F Bartoli-Leonard, J Zimmer… - Cardiovascular research, 2021 - academic.oup.com
Calcific aortic valve disease (CAVD), and its clinical manifestation that is calcific aortic valve
stenosis, is the leading cause for valve disease within the developed world, with no current …
stenosis, is the leading cause for valve disease within the developed world, with no current …
Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts
Fibrotic disease is caused by the continuous deposition of extracellular matrix by persistently
activated fibroblasts (also known as myofibroblasts), even after the resolution of the injury …
activated fibroblasts (also known as myofibroblasts), even after the resolution of the injury …
Programing cell assembly via ink-free, label-free magneto-archimedes based strategy
Tissue engineering raised a high requirement to control cell distribution in defined materials
and structures. In “ink”-based bioprintings, such as 3D printing and photolithography, cells …
and structures. In “ink”-based bioprintings, such as 3D printing and photolithography, cells …
Genes that escape X chromosome inactivation modulate sex differences in valve myofibroblasts
Background: Aortic valve stenosis is a sexually dimorphic disease, with women often
presenting with sustained fibrosis and men with more extensive calcification. However, the …
presenting with sustained fibrosis and men with more extensive calcification. However, the …
Single-cell transcriptomics reveal cellular diversity of aortic valve and the immunomodulation by PPARγ during hyperlipidemia
Valvular inflammation triggered by hyperlipidemia has been considered as an important
initial process of aortic valve disease; however, cellular and molecular evidence remains …
initial process of aortic valve disease; however, cellular and molecular evidence remains …
Matters of the heart: cellular sex differences
Nearly all cardiovascular diseases show sexual dimorphisms in prevalence, presentation,
and outcomes. Until recently, most clinical trials were carried out in males, and many animal …
and outcomes. Until recently, most clinical trials were carried out in males, and many animal …
Uncoupling the vicious cycle of mechanical stress and inflammation in calcific aortic valve disease
Calcific aortic valve disease (CAVD) is a common acquired valvulopathy, which carries a
high burden of mortality. Chronic inflammation has been postulated as the predominant …
high burden of mortality. Chronic inflammation has been postulated as the predominant …
[HTML][HTML] Blocking the NLRP3 inflammasome reduces osteogenic calcification and M1 macrophage polarization in a mouse model of calcified aortic valve stenosis
J Lu, S **e, Y Deng, X **e, Y Liu - Atherosclerosis, 2022 - Elsevier
Background and aims Activated innate immune cells infiltrating the valve and their secreted
cytokines drive the differentiation of valve interstitial cells into myofibroblastic and …
cytokines drive the differentiation of valve interstitial cells into myofibroblastic and …
Facile engineering of interactive double network hydrogels for heart valve regeneration
J Li, W Qiao, Y Liu, H Lei, S Wang, Y Xu, Y Zhou… - Nature …, 2024 - nature.com
Regenerative heart valve prostheses are essential for treating valvular heart disease, which
requested interactive materials that can adapt to the tissue remodeling process. Such …
requested interactive materials that can adapt to the tissue remodeling process. Such …