[HTML][HTML] Tissue architecture in tumor initiation and progression
The 3D architecture of tissues bearing tumors impacts on the mechanical microenvironment
of cancer, the accessibility of stromal cells, and the routes of invasion. A myriad of intrinsic …
of cancer, the accessibility of stromal cells, and the routes of invasion. A myriad of intrinsic …
Immune escape during breast tumor progression
CR Gil Del Alcazar, M Alečković, K Polyak - Cancer immunology research, 2020 - AACR
Immunotherapy using checkpoint inhibitors is one of the most promising current cancer
treatment strategies. However, in breast cancer, its success has been limited to a subset of …
treatment strategies. However, in breast cancer, its success has been limited to a subset of …
Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma
Ductal carcinoma in situ (DCIS) is a pre-invasive lesion that is thought to be a precursor to
invasive breast cancer (IBC). To understand the changes in the tumor microenvironment …
invasive breast cancer (IBC). To understand the changes in the tumor microenvironment …
Circ3823 contributes to growth, metastasis and angiogenesis of colorectal cancer: involvement of miR-30c-5p/TCF7 axis
Y Guo, Y Guo, C Chen, D Fan, X Wu, L Zhao, B Shao… - Molecular cancer, 2021 - Springer
Background Colorectal cancer (CRC) is one of the most common malignant tumours. The
recurrence and metastasis of CRC seriously affect the survival rate of patients. Angiogenesis …
recurrence and metastasis of CRC seriously affect the survival rate of patients. Angiogenesis …
Single cell atlas identifies lipid-processing and immunomodulatory endothelial cells in healthy and malignant breast
V Geldhof, LPMH de Rooij, L Sokol… - Nature …, 2022 - nature.com
Since a detailed inventory of endothelial cell (EC) heterogeneity in breast cancer (BC) is
lacking, here we perform single cell RNA-sequencing of 26,515 cells (including 8433 ECs) …
lacking, here we perform single cell RNA-sequencing of 26,515 cells (including 8433 ECs) …
[HTML][HTML] A human breast atlas integrating single-cell proteomics and transcriptomics
GK Gray, CMC Li, JM Rosenbluth, LM Selfors… - Developmental cell, 2022 - cell.com
The breast is a dynamic organ whose response to physiological and pathophysiological
conditions alters its disease susceptibility, yet the specific effects of these clinical variables …
conditions alters its disease susceptibility, yet the specific effects of these clinical variables …
ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells
AW Lambert, C Fiore, Y Chutake, ER Verhaar… - Developmental cell, 2022 - cell.com
Cancer stem cells (CSCs) may serve as the cellular seeds of tumor recurrence and
metastasis, and they can be generated via epithelial-mesenchymal transitions (EMTs) …
metastasis, and they can be generated via epithelial-mesenchymal transitions (EMTs) …
Neurotrophin signaling is a central mechanism of salivary dysfunction after irradiation that disrupts myoepithelial cells
The mechanisms that prevent regeneration of irradiated (IR) salivary glands remain elusive.
Bulk RNAseq of IR versus non-IR human salivary glands showed that neurotrophin …
Bulk RNAseq of IR versus non-IR human salivary glands showed that neurotrophin …
Hyaluronan mediated motility receptor (HMMR) encodes an evolutionarily conserved homeostasis, mitosis, and meiosis regulator rather than a hyaluronan receptor
Hyaluronan is an extracellular matrix component that absorbs water in tissues and engages
cell surface receptors, like Cluster of Differentiation 44 (CD44), to promote cellular growth …
cell surface receptors, like Cluster of Differentiation 44 (CD44), to promote cellular growth …
Evidence for accelerated aging in mammary epithelia of women carrying germline BRCA1 or BRCA2 mutations
During aging in the human mammary gland, luminal epithelial cells lose lineage fidelity by
expressing markers normally expressed in myoepithelial cells. We hypothesize that loss of …
expressing markers normally expressed in myoepithelial cells. We hypothesize that loss of …