There are approximately 800 annotated G protein–coupled receptor (GPCR) genes, making
these membrane receptors members of the most abundant gene family in the human …

Adhesion G protein‐coupled receptors (aGPCRs) are a class of structurally and functionally
highly intriguing cell surface receptors with essential functions in health and disease. Thus …

Excess osteoclast activity is found in many bone metabolic diseases, and inhibiting
osteoclast differentiation has proven to be an effective strategy. Here, we revealed that …

Enhanced osteoclastogenesis and osteoclast activity contribute to the development of
osteoporosis, which is characterized by increased bone resorption and inadequate bone …

PathDIP was introduced to increase proteome coverage of literature-curated human
pathway databases. PathDIP 4 now integrates 24 major databases. To further reduce the …

Identification and analysis of small molecule bioactivity in target-agnostic cellular assays
and monitoring changes in phenotype followed by identification of the biological target are a …

Melatonin is a bioamine produced primarily in the pineal gland, although peripheral sites,
including the gut, may also be its minor source. Melatonin regulates various functions …

Succinate receptor GPR91 is one of G protein‐coupled receptors (GPCRs), and is
expressed in a variety of cell types and tissues. Succinate is its natural ligand, and its …

Nonalcoholic fatty liver disease (NAFLD) is a broad-spectrum disease, ranging from simple
hepatic steatosis to nonalcoholic steatohepatitis, which can progress to cirrhosis and liver …

Gut microbiota has emerged as an important regulator of bone homeostasis. In particular,
the modulation of innate immunity and bone homeostasis is mediated through the …