Widely developed for clinical screening, electrocardiogram (ECG) recordings capture the
cardiac electrical activity from the body surface. ECG analysis can therefore be a crucial first …

Cardiotoxicity, defined as toxicity that affects the heart, is one of the most common adverse
drug effects. Numerous drugs have been shown to have the potential to induce lethal …

Historically, the evidences of safety and efficacy that companies provide to regulatory
agencies as support to the request for marketing authorization of a new medical product …

Early prediction of cardiotoxicity is critical for drug development. Current animal models
raise ethical and translational questions, and have limited accuracy in clinical risk prediction …

Hypertrophic cardiomyopathy (HCM), the most common inherited heart disease, is still
orphan of a specific drug treatment. The erroneous consideration of HCM as a rare disease …

Human-based computational modelling and simulation are powerful tools to accelerate the
mechanistic understanding of cardiac patho-physiology, and to develop and evaluate …

Cardiotoxicity is a severe side effect of drugs that induce structural or electrophysiological
changes in heart muscle cells. As a result, the heart undergoes failure and potentially lethal …

Rationale: Calcium transient analysis is central to understanding inherited and acquired
cardiac physiology and disease. Although the development of novel calcium reporters …

Acute myocardial ischemia is one of the main causes of sudden cardiac death. The
mechanisms have been investigated primarily in experimental and computational studies …

Abstract The Adverse Outcome Pathway (AOP) concept is a knowledge assembly and
communication tool to facilitate the transparent translation of mechanistic information into …