Biocatalytic cascades are a powerful tool for building complex molecules containing oxygen
and nitrogen functionalities. Moreover, the combination of multiple enzymes in one pot offers …

α, ω-C6 bifunctional compounds play fundamental roles in the synthesis of a variety of value-
added products including polymers, adhesives, pharmaceuticals, perfumes and so on. So …

Colocalization of cascade enzymes is broadly discussed as a phenomenon that can boost
the cascade reaction throughput, although a direct experimental verification is often …

Abstract The chiral N‐substituted 1, 2‐amino alcohol motif is found in many natural and
synthetic bioactive compounds. In this study, enzymatic asymmetric reductive amination of α …

β-Transaminases (β-TAs) have shown considerable potential as biocatalysts for the
synthesis of chiral β-and γ-amino acid. Herein, a (R)-β-TA was successfully created by the …

We developed a multienzyme biocatalytic cascade with high atom efficiency and a self-
sufficient redox network for the synthesis of nylon monomers without adding auxiliary …

Non-canonical amino acids (ncAAs) have been utilized as an invaluable tool for modulating
the active site of the enzymes, probing the complex enzyme mechanisms, improving …

Engineering nonribosomal peptide synthetases (NRPSs) has been a “holy grail” in synthetic
biology due to their modular nature and limited understanding of catalytic mechanisms …

Oxidoreductase-mediated biotransformation often requires consumption of a secondary
sacrificial co-substrate and an additional auxiliary enzyme to drive the cofactor regeneration …

Aliphatic ω‐amino fatty acids (ω‐AFAs) and α, ω‐diamines (α, ω‐DMs) are essential
monomers for the production of nylons. Development of a sustainable biosynthesis route for …