Toward the solution of the protein structure prediction problem
Since Anfinsen demonstrated that the information encoded in a protein's amino acid
sequence determines its structure in 1973, solving the protein structure prediction problem …
sequence determines its structure in 1973, solving the protein structure prediction problem …
Principles and overview of sampling methods for modeling macromolecular structure and dynamics
Investigation of macromolecular structure and dynamics is fundamental to understanding
how macromolecules carry out their functions in the cell. Significant advances have been …
how macromolecules carry out their functions in the cell. Significant advances have been …
Deep‐learning contact‐map guided protein structure prediction in CASP13
We report the results of two fully automated structure prediction pipelines,“Zhang‐Server”
and “QUARK”, in CASP13. The pipelines were built upon the C‐I‐TASSER and C‐QUARK …
and “QUARK”, in CASP13. The pipelines were built upon the C‐I‐TASSER and C‐QUARK …
I-TASSER: a unified platform for automated protein structure and function prediction
The iterative threading assembly refinement (I-TASSER) server is an integrated platform for
automated protein structure and function prediction based on the sequence-to-structure-to …
automated protein structure and function prediction based on the sequence-to-structure-to …
I-TASSER server for protein 3D structure prediction
Y Zhang - BMC bioinformatics, 2008 - Springer
Background Prediction of 3-dimensional protein structures from amino acid sequences
represents one of the most important problems in computational structural biology. The …
represents one of the most important problems in computational structural biology. The …
LOMETS: a local meta-threading-server for protein structure prediction
We developed LOMETS, a local threading meta-server, for quick and automated predictions
of protein tertiary structures and spatial constraints. Nine state-of-the-art threading programs …
of protein tertiary structures and spatial constraints. Nine state-of-the-art threading programs …
Three-dimensional protein structure prediction: Methods and computational strategies
A long standing problem in structural bioinformatics is to determine the three-dimensional (3-
D) structure of a protein when only a sequence of amino acid residues is given. Many …
D) structure of a protein when only a sequence of amino acid residues is given. Many …
Ab initio modeling of small proteins by iterative TASSER simulations
Background Predicting 3-dimensional protein structures from amino-acid sequences is an
important unsolved problem in computational structural biology. The problem becomes …
important unsolved problem in computational structural biology. The problem becomes …
SPICKER: A clustering approach to identify near‐native protein folds
We have developed SPICKER, a simple and efficient strategy to identify near‐native folds by
clustering protein structures generated during computer simulations. In general, the most …
clustering protein structures generated during computer simulations. In general, the most …
Template‐based modeling and free modeling by I‐TASSER in CASP7
Y Zhang - Proteins: Structure, Function, and Bioinformatics, 2007 - Wiley Online Library
We developed and tested the I‐TASSER protein structure prediction algorithm in the CASP7
experiment, where targets are first threaded through the PDB library and continuous …
experiment, where targets are first threaded through the PDB library and continuous …