[HTML][HTML] Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities
Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …
Activity-based protein profiling: Recent advances in medicinal chemistry
H Deng, Q Lei, Y Wu, Y He, W Li - European journal of medicinal chemistry, 2020 - Elsevier
Activity-based protein profiling (ABPP) has become an emerging chemical proteomic
approach to illustrate the interaction mechanisms between compounds and proteins. This …
approach to illustrate the interaction mechanisms between compounds and proteins. This …
Copper-catalyzed transamidation of unactivated secondary amides via C–H and C–N bond simultaneous activations
C Lv, R Zhao, X Wang, D Liu, T Muschin… - The Journal of …, 2023 - ACS Publications
Here, we demonstrate that α-C–H and C–N bonds of unactivated secondary amides can be
activated simultaneously by the copper catalyst to synthesize α-ketoamides or α-ketoesters …
activated simultaneously by the copper catalyst to synthesize α-ketoamides or α-ketoesters …
Chemical probes to control and visualize lipid metabolism in the brain
JM Punt, D van der Vliet… - Accounts of Chemical …, 2022 - ACS Publications
Conspectus Signaling lipids, such as the endocannabinoids, play an important role in the
brain. They regulate synaptic transmission and control various neurophysiological …
brain. They regulate synaptic transmission and control various neurophysiological …
Combining a transcriptomic approach and a targeted metabolomics approach for deciphering the molecular bases of compatibility phenotype in the snail …
Biomphalaria glabrata is a freshwater snail and the obligatory intermediate host of
Schistosoma mansoni parasite, the etiologic agent of intestinal Schistosomiasis, in South …
Schistosoma mansoni parasite, the etiologic agent of intestinal Schistosomiasis, in South …
Use of hypervalent iodine reagents in visible light-promoted α-ketoacylations of sulfoximines with aryl alkynes
In visible light, sulfoximidoyl-containing hypervalent iodine reagents react with aryl alkynes
to give N-α-ketoacylated sulfoximines in good to high yields. The process is metal-and base …
to give N-α-ketoacylated sulfoximines in good to high yields. The process is metal-and base …
Visible-Light-Triggered Synthesis of N-α-Ketoacylated Sulfoximines by Denitrogenative and Oxidative Functionalization of Vinyl Azides
We have introduced a sulfoximidation reaction initiated by visible light between α-phenyl
vinyl azides and NH-sulfoximines. The cost-effective and readily accessible hypervalent …
vinyl azides and NH-sulfoximines. The cost-effective and readily accessible hypervalent …
Visible-Light-Mediated α-Ketoacylations of NH-Sulfoximines with gem-Difluoroalkenes
A photochemical approach for the preparation of α-keto-N-acyl sulfoximines from NH
sulfoximines and gem-difluoroalkenes has been developed. In the presence of NBS, the …
sulfoximines and gem-difluoroalkenes has been developed. In the presence of NBS, the …
Macroscopic inhibition of DNA damage repair pathways by targeting AP-2α with LEI110 eradicates hepatocellular carcinoma
DNA damage repair (DDR) genes are known to be closely associated with the progression
of Hepatocellular carcinoma (HCC). Here we report a unique cluster of “deletion-up” genes …
of Hepatocellular carcinoma (HCC). Here we report a unique cluster of “deletion-up” genes …
Synthesis, single crystal X-ray, DFT, spectroscopic, molecular docking studies and in vitro biological evaluation of compound N-benzyl-4-(4-chlorophenyl)-2 …
Several α-ketoamides from natural as well as synthetic sources have been shown to
possess multitude of biological activities due to their versatile nature and presence of …
possess multitude of biological activities due to their versatile nature and presence of …