Amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized
by the degeneration of both upper and lower motor neurons, which leads to muscle …
by the degeneration of both upper and lower motor neurons, which leads to muscle …
Clinical diagnosis and management of amyotrophic lateral sclerosis
O Hardiman, LH Van Den Berg… - Nature reviews neurology, 2011 - nature.com
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that results in
progressive loss of bulbar and limb function. Patients typically die from respiratory failure …
progressive loss of bulbar and limb function. Patients typically die from respiratory failure …
Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial
PH Gordon, DH Moore, RG Miller, JM Florence… - The Lancet …, 2007 - thelancet.com
Background Minocycline has anti-apoptotic and anti-inflammatory effects in vitro, and
extends survival in mouse models of some neurological conditions. Several trials are …
extends survival in mouse models of some neurological conditions. Several trials are …
[HTML][HTML] Amyotrophic lateral sclerosis: an update for 2013 clinical features, pathophysiology, management and therapeutic trials
PH Gordon - Aging and disease, 2013 - ncbi.nlm.nih.gov
Amyotrophic lateral sclerosis (ALS), first described by Jean-Martin Charcot in the 1870s, is
an age-related disorder that leads to degeneration of motor neurons. The disease begins …
an age-related disorder that leads to degeneration of motor neurons. The disease begins …
Descriptive epidemiology of amyotrophic lateral sclerosis: new evidence and unsolved issues
Amyotrophic lateral sclerosis (ALS) is a relatively rare disease with a reported population
incidence of between 1.5 and 2.5 per 100 000 per year. Over the past 10 years, the design …
incidence of between 1.5 and 2.5 per 100 000 per year. Over the past 10 years, the design …
ARTP statement on pulmonary function testing 2020
The Association for Respiratory Technology & Physiology (ARTP) last produced a statement
on the performance of lung function testing in 1994. At that time the focus was on a practical …
on the performance of lung function testing in 1994. At that time the focus was on a practical …
Home mechanical ventilation: a Canadian Thoracic Society clinical practice guideline
DA McKim, J Road, M Avendano… - Canadian …, 2011 - Wiley Online Library
Increasing numbers of patients are surviving episodes of prolonged mechanical ventilation
or benefitting from the recent availability of user‐friendly noninvasive ventilators. Although …
or benefitting from the recent availability of user‐friendly noninvasive ventilators. Although …
Sleep disturbances in patients with amyotrophic lateral sclerosis: current perspectives
M Boentert - Nature and science of sleep, 2019 - Taylor & Francis
Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease inevitably leading
to generalized muscle weakness and premature death. Sleep disturbances are extremely …
to generalized muscle weakness and premature death. Sleep disturbances are extremely …
Maximum inspiratory pressure as a clinically meaningful trial endpoint for neuromuscular diseases: a comprehensive review of the literature
Respiratory muscle strength is a proven predictor of long-term outcome of neuromuscular
disease (NMD), including amyotrophic lateral sclerosis, Duchenne muscular dystrophy, and …
disease (NMD), including amyotrophic lateral sclerosis, Duchenne muscular dystrophy, and …
Pulmonary issues in patients with chronic neuromuscular disease
JO Benditt, LJ Boitano - American journal of respiratory and critical …, 2013 - atsjournals.org
Patients with chronic neuromuscular diseases such as spinal cord injury, amyotrophic lateral
sclerosis, and muscular dystrophies experience respiratory complications that are cared for …
sclerosis, and muscular dystrophies experience respiratory complications that are cared for …