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Regional specialization within the mammalian respiratory immune system
The respiratory tract is exposed to infection from inhaled pathogens, including viruses,
bacteria, and fungi. So far, a comprehensive assessment that integrates common and …
bacteria, and fungi. So far, a comprehensive assessment that integrates common and …
Linking vaccine adjuvant mechanisms of action to function
Vaccines deliver an immunogen in a manner designed to safely provoke an immune
response, leading to the generation of memory T and B cells and long-lived antibody …
response, leading to the generation of memory T and B cells and long-lived antibody …
[HTML][HTML] Temporal profiling of human lymphoid tissues reveals coordinated defense against viral challenge
ML Coates, N Richoz, ZK Tuong, GS Bowyer… - Nature …, 2025 - nature.com
Adaptive immunity is generated in lymphoid organs, but how these structures defend
themselves during infection in humans is unknown. The nasal epithelium is a major site of …
themselves during infection in humans is unknown. The nasal epithelium is a major site of …
mRNA vaccine-induced IgG mediates nasal SARS-CoV-2 clearance in mice
C Fricke, L Ulrich, J Kochmann, J Gergen… - … Therapy Nucleic Acids, 2024 - cell.com
Coronavirus disease 2019 (COVID-19) mRNA vaccines that have contributed to controlling
the SARS-CoV-2 pandemic induce specific serum antibodies, which correlate with …
the SARS-CoV-2 pandemic induce specific serum antibodies, which correlate with …
A symphony of immunity to SARS-CoV-2 in the adenoids
A symphony of immunity to SARS-CoV-2 in the adenoids | Nature Immunology Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited …
content Thank you for visiting nature.com. You are using a browser version with limited …
B cells in non-lymphoid tissues
B cells have long been understood to be drivers of both humoral and cellular immunity.
Recent advances underscore this importance but also indicate that in infection, inflammatory …
Recent advances underscore this importance but also indicate that in infection, inflammatory …
[HTML][HTML] Early antiviral CD4+ and CD8+ T cells are associated with upper airway clearance of SARS-CoV-2
T cells are involved in protective immunity against numerous viral infections. Data regarding
functional roles of human T cells in SARS-CoV-2 (SARS2) viral clearance in primary COVID …
functional roles of human T cells in SARS-CoV-2 (SARS2) viral clearance in primary COVID …
T-Cell Immune Responses to SARS-CoV-2 Infection and Vaccination
S Notarbartolo - Vaccines, 2024 - mdpi.com
The innate and adaptive immune systems collaborate to detect SARS-CoV-2 infection,
minimize the viral spread, and kill infected cells, ultimately leading to the resolution of the …
minimize the viral spread, and kill infected cells, ultimately leading to the resolution of the …
Airway-resident memory CD4 T cell activation accelerates antigen presentation and T cell priming in draining lymph nodes
CM Finn, K Dhume, E Baffoe, LA Kimball, TM Strutt… - JCI insight, 2025 - insight.jci.org
JCI Insight - Airway-resident memory CD4 T cell activation accelerates antigen presentation
and T cell priming in draining lymph nodes Go to The Journal of Clinical Investigation About …
and T cell priming in draining lymph nodes Go to The Journal of Clinical Investigation About …
[HTML][HTML] Safety, Immunogenicity and Protective Activity of a Modified Trivalent Live Attenuated Influenza Vaccine for Combined Protection Against Seasonal Influenza …
E Stepanova, V Matyushenko, D Mezhenskaya… - Vaccines, 2024 - pmc.ncbi.nlm.nih.gov
Background/Objectives: Influenza viruses and SARS-CoV-2 are currently cocirculating with
similar seasonality, and both pathogens are characterized by a high mutational rate which …
similar seasonality, and both pathogens are characterized by a high mutational rate which …