The rising interest for precise characterization of the tumour immune contexture has recently
brought forward the high potential of RNA sequencing (RNA-seq) in identifying molecular …

Tumor progression and the efficacy of immunotherapy are strongly influenced by the
composition and abundance of immune cells in the tumor microenvironment. Due to the …

Local immunotherapy ideally stimulates immune responses against tumors while avoiding
toxicities associated with systemic administration. Current strategies for tumor-targeted …

Despite the remarkable clinical success of immunotherapies in a subset of cancer patients,
many fail to respond to treatment and exhibit resistance. Here, we found that genetic or …

Methods for in silico deconvolution of bulk transcriptomics can characterize the cellular
composition of the tumor microenvironment, quantifying the abundance of cell types …

Background New precision medicine therapies are urgently required for glioblastoma
(GBM). However, to date, efforts to subtype patients based on molecular profiles have failed …

Anti-angiogenic cancer therapies possess immune-stimulatory properties by counteracting
pro-angiogenic molecular mechanisms. We report that tumor endothelial cells ubiquitously …

Syngeneic mouse models are tumors derived from murine cancer cells engrafted on
genetically identical mouse strains. They are widely used tools for studying tumor immunity …

Cancer cells exhibit metabolic plasticity to meet oncogene-driven dependencies while
co** with nutrient availability. A better understanding of how systemic metabolism impacts …

Objective Intrahepatic cholangiocarcinoma (iCCA) is rising in incidence, and at present,
there are limited effective systemic therapies. iCCA tumours are infiltrated by stromal cells …