Work performed with differentiated contractile smooth muscle tissue over the last two
decades has made clear that covalent modification of myosin by phosphorylation of the 20 …

Hyperglycemia is the major causal factor in the development of diabetic vascular
complications and can mediate their adverse effects through multiple pathways. One of …

The intracellular pathogenic bacterium L. monocytogenes can spread directly from cell to
cell without leaving the cytoplasm. The mechanism of this movement, generated through …

Calponin isolated from chicken gizzard smooth muscle inhibits the actin-activated
MgATPase activity of smooth muscle myosin in a reconstituted system composed of …

Dicer is an evolutionarily conserved ribonuclease III that is necessary for microRNA (miRNA)
processing and the synthesis of small interfering RNAs from long double-stranded RNA …

Caldesmon is a major calmodulin-and actin-binding protein found in smooth muscle and
nonmuscle cells (Ref. 1, and reviewed in Ref. 2). Current studies suggest a vital role for this …

OBJECTIVES: Benign prostatic hyperplasia (BPH) is considered a frequent cause of bladder
outlet obstruction (BOO) and lower urinary tract symptoms (LUTS), although the …

Expression of the regulatory contractile proteins, heavy caldesmon (h-caldesmon) and
calponin was studied in human aortic smooth muscle cells (SMCs) during development and …

Calmodulin, the ubiquitous and multifunctional Ca 2+-binding protein, mediates many of the
regulatory effects of Ca 2+, including the contractile state of smooth muscle. The principal …

To learn more about how dyneins are targeted to specific sites in the flagellum, we have
investigated a factor necessary for binding of outer arm dynein to the axonemal microtubules …