[HTML][HTML] GPCR homo-oligomerization
G Milligan, RJ Ward, S Marsango - Current opinion in cell biology, 2019 - Elsevier
G protein-coupled receptors (GPCRs) are an extensive class of trans-plasma membrane
proteins that function to regulate a wide range of physiological functions. Despite a general …
proteins that function to regulate a wide range of physiological functions. Despite a general …
The endocannabinoid system as a target in cancer diseases: are we there yet?
The endocannabinoid system (ECS) has been placed in the anti-cancer spotlight in the last
decade. The immense data load published on its dual role in both tumorigenesis and …
decade. The immense data load published on its dual role in both tumorigenesis and …
Single-molecule FRET imaging of GPCR dimers in living cells
WB Asher, P Geggier, MD Holsey, GT Gilmore… - Nature …, 2021 - nature.com
Class CG protein-coupled receptors (GPCRs) are known to form stable homodimers or
heterodimers critical for function, but the oligomeric status of class A and B receptors, which …
heterodimers critical for function, but the oligomeric status of class A and B receptors, which …
Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor
J Liu, H Tang, C Xu, S Zhou, X Zhu, Y Li… - Nature …, 2022 - nature.com
G protein-coupled receptors (GPCRs) are important drug targets that mediate various
signaling pathways by activating G proteins and engaging β-arrestin proteins. Despite its …
signaling pathways by activating G proteins and engaging β-arrestin proteins. Despite its …
Advanced fluorescence microscopy reveals disruption of dynamic CXCR4 dimerization by subpocket-specific inverse agonists
A Işbilir, J Möller, M Arimont, V Bobkov… - Proceedings of the …, 2020 - National Acad Sciences
Although class AG protein− coupled receptors (GPCRs) can function as monomers, many of
them form dimers and oligomers, but the mechanisms and functional relevance of such …
them form dimers and oligomers, but the mechanisms and functional relevance of such …
Non-canonical interplay between glutamatergic NMDA and dopamine receptors shapes synaptogenesis
N Bénac, G Ezequiel Saraceno, C Butler… - Nature …, 2024 - nature.com
Direct interactions between receptors at the neuronal surface have long been proposed to
tune signaling cascades and neuronal communication in health and disease. Yet, the lack of …
tune signaling cascades and neuronal communication in health and disease. Yet, the lack of …
The class-A GPCR dopamine D2 receptor forms transient dimers stabilized by agonists: detection by single-molecule tracking
Whether class-A G-protein coupled receptors (GPCRs) exist and work as monomers or
dimers has drawn extensive attention. A class-A GPCR dopamine D2 receptor (D2R) is …
dimers has drawn extensive attention. A class-A GPCR dopamine D2 receptor (D2R) is …
Quantitative evaluation of methods to analyze motion changes in single-particle experiments
G Muñoz-Gil, H Bachimanchi, J Pineda… - ar** a method to
measure the activities of GPCRs is essential for pharmacology and drug screening …
measure the activities of GPCRs is essential for pharmacology and drug screening …
[HTML][HTML] Detergent-free extraction of a functional low-expressing GPCR from a human cell line
Dopamine receptors (DRs) are class A G-Protein Coupled Receptors (GPCRs) prevalent in
the central nervous system (CNS). These receptors mediate physiological functions ranging …
the central nervous system (CNS). These receptors mediate physiological functions ranging …