G protein-coupled receptors (GPCRs) are an extensive class of trans-plasma membrane
proteins that function to regulate a wide range of physiological functions. Despite a general …

The endocannabinoid system (ECS) has been placed in the anti-cancer spotlight in the last
decade. The immense data load published on its dual role in both tumorigenesis and …

Class CG protein-coupled receptors (GPCRs) are known to form stable homodimers or
heterodimers critical for function, but the oligomeric status of class A and B receptors, which …

G protein-coupled receptors (GPCRs) are important drug targets that mediate various
signaling pathways by activating G proteins and engaging β-arrestin proteins. Despite its …

Although class AG protein− coupled receptors (GPCRs) can function as monomers, many of
them form dimers and oligomers, but the mechanisms and functional relevance of such …

Direct interactions between receptors at the neuronal surface have long been proposed to
tune signaling cascades and neuronal communication in health and disease. Yet, the lack of …

Whether class-A G-protein coupled receptors (GPCRs) exist and work as monomers or
dimers has drawn extensive attention. A class-A GPCR dopamine D2 receptor (D2R) is …

Chemokines are cytokines whose primary role is cellular activation and stimulation of
leukocyte migration. They perform their various functions by interacting with G protein …