Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases

Y Shi, Y Wang, Q Li, K Liu, J Hou, C Shao… - Nature Reviews …, 2018 - nature.com
Mesenchymal stem cells (MSCs; also referred to as mesenchymal stromal cells) have
attracted much attention for their ability to regulate inflammatory processes. Their therapeutic …

Mesenchymal stem cells in health and disease

A Uccelli, L Moretta, V Pistoia - Nature reviews immunology, 2008 - nature.com
Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal stem cells that can
be isolated from many adult tissues. They can differentiate into cells of the mesodermal …

Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study

K Le Blanc, F Frassoni, L Ball, F Locatelli, H Roelofs… - The Lancet, 2008 - thelancet.com
Background Severe graft-versus-host disease (GVHD) is a life-threatening complication after
allogeneic transplantation with haemopoietic stem cells. Mesenchymal stem cells modulate …

Gene therapy using haematopoietic stem and progenitor cells

G Ferrari, AJ Thrasher, A Aiuti - Nature Reviews Genetics, 2021 - nature.com
Haematopoietic stem and progenitor cell (HSPC) gene therapy has emerged as an effective
treatment modality for monogenic disorders of the blood system such as primary …

Regenerative capacity of adipose derived stem cells (ADSCs), comparison with mesenchymal stem cells (MSCs)

L Mazini, L Rochette, M Amine, G Malka - International journal of …, 2019 - mdpi.com
Adipose tissue is now on the top one of stem cell sources regarding its accessibility,
abundance, and less painful collection procedure when compared to other sources. The …

Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study

M Duijvestein, ACW Vos, H Roelofs, ME Wildenberg… - Gut, 2010 - gut.bmj.com
Background and aim Mesenchymal stromal cells (MSCs) are pluripotent cells that have
immunosuppressive effects both in vitro and in experimental colitis. Promising results of …

MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin …

GM Spaggiari, H Abdelrazik… - Blood, The Journal of …, 2009 - ashpublications.org
Various studies analyzed the inhibitory effect exerted by mesenchymal stem cells (MSCs) on
cells of the innate or acquired immunity. Myeloid dendritic cells (DCs) are also susceptible to …

Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn's disease

R Ciccocioppo, ME Bernardo, A Sgarella, R Maccario… - Gut, 2011 - gut.bmj.com
Objective External fistulas represent a disabling manifestation of Crohn's disease with a
difficult curability and a high relapse rate despite a large therapeutic armamentarium. Stem …

Adipose tissue-derived multipotent stromal cells have a higher immunomodulatory capacity than their bone marrow-derived counterparts

SM Melief, JJ Zwaginga, WE Fibbe… - Stem cells translational …, 2013 - academic.oup.com
Adipose tissue-derived multipotent stromal cells (AT-MSCs) are studied as an alternative to
bone marrow-derived multipotent stromal cells (BM-MSCs) for immunomodulatory treatment …

Mesenchymal stem or stromal cells: a review of clinical applications and manufacturing practices

RR Sharma, K Pollock, A Hubel, D McKenna - Transfusion, 2014 - Wiley Online Library
Mesenchymal stem cells (MSC s) have recently generated great interest in the fields of
regenerative medicine and immunotherapy due to their unique biologic properties. In this …