Ice flavours and non-menthol synthetic cooling agents in e-cigarette products: a review

AM Leventhal, AP Tackett, L Whitted… - Tobacco …, 2023 - tobaccocontrol.bmj.com
E-cigarettes with cooling flavours have diversified in ways that complicate tobacco control
with the emergence of:(1) Ice-hybrid flavours (eg,'Raspberry Ice') that combine cooling and …

The distinctive role of menthol in pain and analgesia: Mechanisms, practices, and advances

Z Li, H Zhang, Y Wang, Y Li, Q Li… - Frontiers in Molecular …, 2022 - frontiersin.org
Menthol is an important flavoring additive that triggers a cooling sensation. Under
physiological condition, low to moderate concentrations of menthol activate transient …

Synthetic cooling agents in US-marketed e-cigarette refill liquids and popular disposable e-cigarettes: chemical analysis and risk assessment

SV Jabba, HC Erythropel, DG Torres… - Nicotine and …, 2022 - academic.oup.com
Introduction Menthol, through its cooling and pleasant sensory effects, facilitates smoking
and tobacco product initiation, resulting in the high popularity of mint/menthol-flavored E …

[HTML][HTML] Interactions between chemesthesis and taste: role of TRPA1 and TRPV1

MR Rhyu, Y Kim, V Lyall - International journal of molecular sciences, 2021 - mdpi.com
In addition to the sense of taste and olfaction, chemesthesis, the sensation of irritation,
pungency, cooling, warmth, or burning elicited by spices and herbs, plays a central role in …

The biological impact of menthol on tobacco dependence

RJ Wickham - Nicotine and Tobacco Research, 2020 - academic.oup.com
In the 1920s, tobacco companies created a marketing campaign for what would one day be
their most profitable series of products: mentholated tobacco cigarettes. Menthol provides …

Synthetic cooling agent in oral nicotine pouch products marketed as 'Flavour-Ban Approved'

SV Jabba, HC Erythropel, JG Woodrow… - Tobacco …, 2025 - tobaccocontrol.bmj.com
Background US sales of oral nicotine pouches (ONPs) have rapidly increased, with
cool/mint-flavoured ONPs the most popular flavour category. Restrictions on sales of …

[HTML][HTML] Why flavored vape products may be attractive: green apple tobacco flavor elicits reward-related behavior, upregulates nAChRs on VTA dopamine neurons …

AJ Avelar, AT Akers, ZJ Baumgard, SY Cooper… - …, 2019 - Elsevier
While nicotine is the primary addictive component in tobacco products, additional flavors
have become a concern with the growing popularity of electronic nicotine delivery systems …

[HTML][HTML] Nicotine formulations impact reinforcement-related behaviors in a mouse model of vapor self-administration

BJ Henderson, SY Cooper - Drug and alcohol dependence, 2021 - Elsevier
Background Electronic nicotine delivery systems (ENDS) differ from combustible cigarettes
given that nicotine-salt or nicotine-freebase may be used depending on the product. We …

Menthol enhances nicotine reward-related behavior by potentiating nicotine-induced changes in nAChR function, nAChR upregulation, and DA neuron excitability

BJ Henderson, TR Wall, BM Henley, CH Kim… - …, 2017 - nature.com
Understanding why the quit rate among smokers of menthol cigarettes is lower than non-
menthol smokers requires identifying the neurons that are altered by nicotine, menthol, and …

Studying the interactive effects of menthol and nicotine among youth: an examination using e-cigarettes

S Krishnan-Sarin, BG Green, G Kong… - Drug and Alcohol …, 2017 - Elsevier
Background Tobacco products containing menthol are widely used by youth. We used e-
cigarettes to conduct an experimental evaluation of the independent and interactive effects …