There is an urgent need to identify novel therapies for childhood cancers. Neuroblastoma is
the most common pediatric solid tumor, and accounts for~ 15% of childhood cancer‐related …

ABSTRACT A vast array of oncogenic variants has been identified for anaplastic lymphoma
kinase (ALK). Therefore, there is a need to better understand the role of ALK in cancer …

Neuroblastoma, the most common extracranial solid tumor of childhood, is thought to
originate from undifferentiated neural crest cells. Amplification of the MYC family member …

The burgeoning field of anaplastic lymphoma kinase (ALK) in cancer encompasses many
cancer types, from very rare cancers to the more prevalent non-small-cell lung cancer …

Summary The ALK F1174L mutation is associated with intrinsic and acquired resistance to
crizotinib and cosegregates with MYCN in neuroblastoma. In this study, we generated a …

Neuroblastoma (NB) is the most common and deadly solid tumour in children. Despite the
development of new treatment options for high-risk NB, over half of patients relapse and five …

As a receptor tyrosine kinase of insulin receptor (IR) subfamily, anaplastic lymphoma kinase
(ALK) has been validated to play important roles in various cancers, especially anaplastic …

Activating anaplastic lymphoma kinase (ALK) mutations were recently detected in most
familial and 10% of sporadic neuroblastomas. However, the role of mutated ALK in …

Clinical outcome remains poor in patients with high-risk neuroblastoma, in which
chemoresistant relapse is common following high-intensity conventional multimodal therapy …

Over the last decade, anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase (RTK),
has been identified as a fusion partner in a diverse variety of translocation events resulting …