Type 2 diabetes: principles of pathogenesis and therapy
Type 2 diabetes mellitus has become an epidemic, and virtually no physician is without
patients who have the disease. Whereas insulin insensitivity is an early phenomenon partly …
patients who have the disease. Whereas insulin insensitivity is an early phenomenon partly …
Proteostasis of islet amyloid polypeptide: a molecular perspective of risk factors and protective strategies for type II diabetes
The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …
β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes
Type 2 diabetes is characterized by impaired insulin secretion. Some but not all studies
suggest that a decrease in β-cell mass contributes to this. We examined pancreatic tissue …
suggest that a decrease in β-cell mass contributes to this. We examined pancreatic tissue …
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
Abstract Interleukin 1β (IL-1β) is an important inflammatory mediator of type 2 diabetes. Here
we show that oligomers of islet amyloid polypeptide (IAPP), a protein that forms amyloid …
we show that oligomers of islet amyloid polypeptide (IAPP), a protein that forms amyloid …
Islet amyloid polypeptide, islet amyloid, and diabetes mellitus
P Westermark, A Andersson… - Physiological …, 2011 - journals.physiology.org
Islet amyloid polypeptide (IAPP, or amylin) is one of the major secretory products of β-cells of
the pancreatic islets of Langerhans. It is a regulatory peptide with putative function both …
the pancreatic islets of Langerhans. It is a regulatory peptide with putative function both …
Amyloid pores from pathogenic mutations
Alzheimer's and Parkinson's diseases are associated with the formation in the brain of
amyloid fibrils from β-amyloid and α-synuclein proteins, respectively. It is likely that …
amyloid fibrils from β-amyloid and α-synuclein proteins, respectively. It is likely that …
Insulin in the brain: its pathophysiological implications for States related with central insulin resistance, type 2 diabetes and Alzheimer's disease
E Blázquez, E Velázquez… - Frontiers in …, 2014 - frontiersin.org
Although the brain has been considered an insulin-insensitive organ, recent reports on the
location of insulin and its receptors in the brain have introduced new ways of considering …
location of insulin and its receptors in the brain have introduced new ways of considering …
Increased risk of type 2 diabetes in Alzheimer disease
J Janson, T Laedtke, JE Parisi, P O'Brien… - Diabetes, 2004 - Am Diabetes Assoc
Alzheimer disease and type 2 diabetes are characterized by increased prevalence with
aging, a genetic predisposition, and comparable pathological features in the islet and brain …
aging, a genetic predisposition, and comparable pathological features in the islet and brain …
The importance of β-cell failure in the development and progression of type 2 diabetes
SE Kahn - The Journal of Clinical Endocrinology & Metabolism, 2001 - academic.oup.com
The pathogenesis of type 2 diabetes is complex and in most instances clearly requires
defects in both ß-cell function and insulin sensitivity (1). Together, these abnormalities result …
defects in both ß-cell function and insulin sensitivity (1). Together, these abnormalities result …
Structural classification of toxic amyloid oligomers
CG Glabe - Journal of Biological Chemistry, 2008 - ASBMB
Amyloid oligomers are believed to play important causal roles in many types of amyloid-
related degenerative diseases. Many different laboratories have reported amyloid oligomers …
related degenerative diseases. Many different laboratories have reported amyloid oligomers …