Possible chemical and physical scenarios towards biological homochirality
The single chirality of biological molecules in terrestrial biology raises more questions than
certitudes about its origin. The emergence of biological homochirality (BH) and its …
certitudes about its origin. The emergence of biological homochirality (BH) and its …
Designing single chirality via crystallization method: spontaneous chiral symmetry breaking and deracemization
Obtaining pure enantiomers is crucial since the two enantiomers of chiral compounds can
exhibit vastly different optical, biological, and pharmacological properties. Two mixed …
exhibit vastly different optical, biological, and pharmacological properties. Two mixed …
Microwave-assisted automated glycan assembly
Automated synthesis of DNA, RNA, and peptides provides quickly and reliably important
tools for biomedical research. Automated glycan assembly (AGA) is significantly more …
tools for biomedical research. Automated glycan assembly (AGA) is significantly more …
Enabling technologies for process intensification in pharmaceutical research and manufacturing
A perspective is given on the status and outlook of enabling technologies for process
intensification in pharmaceutical research and manufacturing. We focus on three areas …
intensification in pharmaceutical research and manufacturing. We focus on three areas …
Population-based mathematical model of solid-state deracemization via temperature cycles
Recently, temperature cycles have been shown to lead to total deracemization of
conglomerate forming compounds, in the presence of a racemizing agent. Even though …
conglomerate forming compounds, in the presence of a racemizing agent. Even though …
[HTML][HTML] A synthetic machine learning framework for complex crystallization processes: The case study of the second-order asymmetric transformation of enantiomers
Improving the flexibility and capabilities of pharmaceutical technologies and lowering the
process development time while satisfying regulatory constraints translate to highly desired …
process development time while satisfying regulatory constraints translate to highly desired …
On Solute Recovery and Productivity in Chiral Resolution through Solid-State Deracemization by Temperature Cycling
Temperature cycling represents an effective means for the deracemization of chiral
compounds that crystallize as conglomerates and racemize in solution. In such a process, a …
compounds that crystallize as conglomerates and racemize in solution. In such a process, a …
Advanced mechanisms and applications of microwave-assisted synthesis of carbon-based materials: a brief review
The interaction of microwave radiation with carbon-based materials induces rapid,
instantaneous heating. When combined with the plasma excitation capabilities of …
instantaneous heating. When combined with the plasma excitation capabilities of …
Deracemization of sodium chlorate by hydrodynamic attrition of Taylor vortex flow
We investigated the deracemization of sodium chlorate in the unique hydrodynamic
environment of Taylor vortex flow (TVF) in Couette-Taylor (CT) crystallizer. Our findings …
environment of Taylor vortex flow (TVF) in Couette-Taylor (CT) crystallizer. Our findings …
Solid-state deracemization via temperature cycles in continuous operation: Model-based process design
Solid-state deracemization via temperature cycles converts a racemic crystal mixture into an
enantiopure product by periodic cycling of the temperature in the presence of a racemization …
enantiopure product by periodic cycling of the temperature in the presence of a racemization …