Huntington's disease (HD) is an autosomal dominant genetic disorder caused by an
expansion of the CAG repeat in the first exon of Huntingtin's gene. The associated …

Cholesterol is a key component of the cell membrane that impacts the permeability, fluidity,
and functions of membrane-bound proteins. It also participates in synaptogenesis, synaptic …

Polyglutamine diseases are a group of neurodegenerative disorders caused by an
abnormal expansion of CAG repeat tracts in the codifying regions of nine, otherwise …

Many neurodegenerative diseases are associated with pathological aggregation of proteins
in neurons. Autophagy is a natural self‐cannibalization process that can act as a powerful …

Accumulating evidence from clinical, genetic, and epidemiologic studies suggest that
schizophrenia might be a neuronal development disorder. While oxysterols are important …

Cytochrome P450s (CYPs) and UDP-glucuronosyltransferases (UGTs) are both greatly
important metabolic enzymes in various tissues, including brain. Although expressions of …

Alcohol intake can impair brain function, in addition to other organs such as the liver and
kidney. In the brain ethanol can be detrimental to memory formation, through inducing the …

Prion diseases are incurable, infectious and fatal neurodegenerative diseases that affect
both humans and animals. The pathogenesis of prion disease involves the misfolding of the …

Neuropsychiatric diseases (NPDs) are severe, debilitating psychiatric conditions that affect
the nervous system. These are among the most challenging disorders in medicine. Some …

A growing body of evidence suggests a correlation between cholesterol metabolism and the
pathogenesis of Parkinson's disease (PD). We and others have demonstrated that the …