[HTML][HTML] Organs-on-chips technologies–A guide from disease models to opportunities for drug development

AG Monteduro, S Rizzato, G Caragnano… - Biosensors and …, 2023 - Elsevier
Current in-vitro 2D cultures and animal models present severe limitations in recapitulating
human physiopathology with striking discrepancies in estimating drug efficacy and side …

Musculoskeletal Organs‐on‐Chips: An Emerging Platform for Studying the Nanotechnology–Biology Interface

Y Wang, P Yung, G Lu, Y Liu, C Ding, C Mao… - Advanced …, 2025 - Wiley Online Library
Nanotechnology‐based approaches are promising for the treatment of musculoskeletal
(MSK) disorders, which present significant clinical burdens and challenges, but their clinical …

Sensitive and specific CRISPR-Cas12a assisted nanopore with RPA for Monkeypox detection

MA Ahamed, MAU Khalid, M Dong, AJ Politza… - Biosensors and …, 2024 - Elsevier
Monkeypox virus (MPXV) poses a global health emergency, necessitating rapid, simple, and
accurate detection to manage its spread effectively. The Clustered Regularly Interspaced …

Advances in TEER measurements of biological barriers in microphysiological systems

H Nazari, J Shrestha, VY Naei, SR Bazaz… - Biosensors and …, 2023 - Elsevier
Biological barriers are multicellular structures that precisely regulate the transport of ions,
biomolecules, drugs, cells, and other organisms. Transendothelial/epithelial electrical …

Revolutionizing drug development: harnessing the potential of organ-on-chip technology for disease modeling and drug discovery

N Sunildutt, P Parihar… - Frontiers in …, 2023 - frontiersin.org
The inefficiency of existing animal models to precisely predict human pharmacological
effects is the root reason for drug development failure. Microphysiological system/organ-on …

[HTML][HTML] Microfluidic organ-on-a-chip devices for liver disease modeling in vitro

P Kanabekova, A Kadyrova, G Kulsharova - Micromachines, 2022 - mdpi.com
Mortality from liver disease conditions continues to be very high. As liver diseases manifest
and progress silently, prompt measures after diagnosis are essential in the treatment of …

Organ-on-a-chip platforms integrated with biosensors for precise monitoring of the cells and cellular microenvironment

W Yang, T Li, S Liao, J Zhou, L Huang - TrAC Trends in Analytical …, 2024 - Elsevier
Abstract Organs-on-chips (OoCs) are in vitro models that simulate the anatomical and
physiological structure of human organs at the micro-scale level. With the advantages of …

Recent advances in Organ-on-a-Chip models: How precision engineering integrates cutting edge technologies in fabrication and characterization

S Sadeghzade, MH Hooshiar, H Akbari… - Applied Materials …, 2024 - Elsevier
There is an increasing need for better preclinical therapeutic development models suitable
for the human body. As a result, there has been a shift from traditional animal models to …

[HTML][HTML] Algae-derived bioactive compounds as potential pharmaceuticals for cancer therapy: A comprehensive review

LA Minhas, M Kaleem, HMU Farooqi, F Kausar… - Algal Research, 2024 - Elsevier
Cancer is considered a pandemic, costing precious lives throughout the globe. Besides its
deadly outcomes, the survival rate after cancer therapies is meager. Anti-cancer drug …

High performance inkjet printed embedded electrochemical sensors for monitoring hypoxia in a gut bilayer microfluidic chip

MAU Khalid, KH Kim, ARC Salih, K Hyun, SH Park… - Lab on a Chip, 2022 - pubs.rsc.org
Sensing devices have shown tremendous potential for monitoring state-of-the-art organ chip
devices. However, challenges like miniaturization while maintaining higher performance …