Epigenetics of autism spectrum disorder: Histone deacetylases
The etiology of autism spectrum disorder (ASD) remains unknown, but gene-environment
interactions, mediated through epigenetic mechanisms, are thought to be a key contributing …
interactions, mediated through epigenetic mechanisms, are thought to be a key contributing …
Structure, mechanism, and inhibition of the zinc-dependent histone deacetylases
Zinc-dependent histone deacetylases (HDACs) regulate the biological function of histone
and non-histone proteins through the hydrolysis of acetyllysine side chains to yield free …
and non-histone proteins through the hydrolysis of acetyllysine side chains to yield free …
Intrinsic structural dynamics dictate enzymatic activity and inhibition
Enzymes are known to sample various conformations, many of which are critical for their
biological function. However, structural characterizations of enzymes predominantly focus …
biological function. However, structural characterizations of enzymes predominantly focus …
Cryo-EM structure of the Saccharomyces cerevisiae Rpd3L histone deacetylase complex
AB Patel, J Qing, KH Tam, S Zaman, M Luiso… - Nature …, 2023 - nature.com
The Rpd3L histone deacetylase (HDAC) complex is an ancient 12-subunit complex
conserved in a broad range of eukaryotes that performs localized deacetylation at or near …
conserved in a broad range of eukaryotes that performs localized deacetylation at or near …
Histone deacetylases as targets for the treatment of neurodegenerative disorders: Challenges and future opportunities
Despite the applicability of histone deacetylase inhibitors (HDACis) for cancer treatment,
several works in the literature have shown that these inhibitors can be used in several other …
several works in the literature have shown that these inhibitors can be used in several other …
Targeting histone deacetylase 8 as a therapeutic approach to cancer and neurodegenerative diseases
A Chakrabarti, J Melesina, FR Kolbinger… - Future medicinal …, 2016 - Taylor & Francis
Histone deacetylase 8 (HDAC8), a unique class I zinc-dependent HDAC, is an emerging
target in cancer and other diseases. Its substrate repertoire extends beyond histones to …
target in cancer and other diseases. Its substrate repertoire extends beyond histones to …
Cannabinoid receptor subtype 2 (CB2R) in a multitarget approach: perspective of an innovative strategy in cancer and neurodegeneration
The cannabinoid receptor subtype 2 (CB2R) represents an interesting and new therapeutic
target for its involvement in the first steps of neurodegeneration as well as in cancer onset …
target for its involvement in the first steps of neurodegeneration as well as in cancer onset …
[HTML][HTML] Utilization of AlphaFold models for drug discovery: Feasibility and challenges. Histone deacetylase 11 as a case study
Abstract Histone deacetylase 11 (HDAC11), an enzyme that cleaves acyl groups from
acylated lysine residues, is the sole member of class IV of HDAC family with no reported …
acylated lysine residues, is the sole member of class IV of HDAC family with no reported …
Innovative strategies for selective inhibition of histone deacetylases
Histone deacetylases (HDAC) are a family of closely related enzymes involved in epigenetic
and posttranscriptional regulation of numerous genes and proteins. Their deregulation is …
and posttranscriptional regulation of numerous genes and proteins. Their deregulation is …
Dissection of the interaction between the intrinsically disordered YAP protein and the transcription factor TEAD
Y Mesrouze, F Bokhovchuk, M Meyerhofer, P Fontana… - Elife, 2017 - elifesciences.org
TEAD (TEA/ATTS d omain) transcription factors are the most distal effectors of the Hippo
pathway. YAP (Y es-a ssociated p rotein) is a coactivator protein which, upon binding to …
pathway. YAP (Y es-a ssociated p rotein) is a coactivator protein which, upon binding to …