The nasal route has been used for many years for the local treatment of nasal diseases.
More recently, this route has been gaining momentum, due to the possibility of targeting the …

Delivery of therapeutics to the central nervous system for treating psychiatric and
neurodegenerative disorders, such as Parkinson's disease and Alzheimer's disease, is a …

For centuries, intranasal administration has been a perennial fascination for humanity. In
recent times, the realm of nanotechnology-based biomaterials has witnessed a notable …

The advancement of effective nasal mucoadhesive delivery faces challenges due to rapid
mucociliary clearance (MCC). Conventional studies have employed mucoadhesive …

The development of paclitaxel-loaded polymeric nanoparticles for the treatment of brain
tumors was investigated. Poly (lactide-glycolide)(PLGA) nanoparticles containing 10% w/w …

Nasal systemic drug delivery may provide an easy way to substitute parenteral or oral
dosing, however, the excipients have an important role in nasal formulations to increase the …

The administration of hydrophilic therapeutics has always been a great challenge because
of their low bioavailability after administration. For this purpose, W/O/W microemulsion …

Schizophrenia is a mental disorder characterized by alterations in cognition, behavior and
emotions. Oral olanzapine (OZ) administration is extensively metabolized (~ up to 40% of …

Proteins and hormones have a wide range of therapeutic uses that have emerged
throughout the years. The increase in their clinical application nowadays has outgrown the …

Nose-to-brain (N2B) drug delivery is a new approach to neurological disorder therapy as
medications can bypass the blood-brain barrier and directly enter the brain. However, the …