Almost all outer membrane proteins (OMPs) in Gram-negative bacteria contain a β-barrel
domain that spans the outer membrane (OM). To reach the OM, OMPs must be translocated …

Recent studies applying advanced imaging techniques are changing the way we
understand bacterial cell surfaces, bringing new knowledge on everything from single-cell …

The outer membrane is a formidable barrier that protects Gram-negative bacteria against
environmental threats. Its integrity requires the correct folding and insertion of outer …

Transmembrane β barrel proteins are folded into the outer membrane (OM) of Gram-
negative bacteria by the β barrel assembly machinery (BAM) via a poorly understood …

BamA is the central component of the essential β-barrel assembly machine (BAM), a
conserved multi-subunit complex that dynamically inserts and folds β-barrel proteins into the …

Membrane proteins (MPs) play essential roles in numerous cellular processes. Because
around 70% of the currently marketed drugs target MPs, a detailed understanding of their …

In Gram-negative bacteria, the biogenesis of β-barrel outer membrane proteins is mediated
by the β-barrel assembly machinery (BAM). The mechanism employed by BAM is complex …

The Omp85 protein superfamily is found in the outer membrane (OM) of all gram-negative
bacteria and eukaryotic organelles of bacterial origin. Members of the family catalyze both …

The t ranslocation and a ssembly m odule (TAM) has been proposed to play a crucial role in
the assembly of a small subset of outer membrane proteins (OMPs) in Proteobacteria based …

The assembly of β-barrel proteins into the bacterial outer membrane is an essential process
enabling the colonization of new environmental niches. The TAM was discovered as a …