Whole genome sequencing (WGS) is becoming the preferred method for molecular genetic
diagnosis of rare and unknown diseases and for identification of actionable cancer drivers …

Modern health care faces several serious challenges, including an ageing population and
its inherent burden of chronic diseases, rising costs and marginal quality metrics. By …

Importance Coronary artery calcium score and polygenic risk score have each separately
been proposed as novel markers to identify risk of coronary heart disease (CHD), but no …

Cumulative exposure to low-density lipoprotein cholesterol (LDL-C) is a key driver of
atherosclerotic cardiovascular disease (ASCVD) risk. An armamentarium of therapies to …

Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality
worldwide and challenges the capacity of health care systems globally. Atherosclerosis is …

BACKGROUND The genetic composition of embryos generated by in vitro fertilization (IVF)
can be examined with preimplantation genetic testing (PGT). Until recently, PGT was limited …

Cardiometabolic diseases, including cardiovascular disease and diabetes, are major
causes of morbidity and mortality worldwide. Despite progress in prevention and treatment …

Clinical implementation of new prediction models requires evaluation of their utility in a
broad range of intended use populations. Here we develop and validate ancestry-specific …

Background and Aims A cardiovascular disease polygenic risk score (CVD-PRS) can stratify
individuals into different categories of cardiovascular risk, but whether the addition of a CVD …

Aims The aim of the study was to assess the real-world feasibility, acceptability, and impact
of an integrated risk tool for cardiovascular disease (CVD IRT, combining the standard …